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FEXOFENADINE
SynDRA canonical compound SYN0002538 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HRH1 |
|---|
| Mechanism of action | Histamine receptor antagonist |
|---|
| Indication | allergic rhinitis | urticaria |
|---|
| Disease area | allergy |
|---|
All known targets
- HRH1
- ABCB1
- KCNH2
- SLCO1A2
- CYP2J2
- KCNH1
- DRD1
- DRD2
- SLC6A2
- HTR2A
- HTR2B
- HTR2C
Mechanisms of action (all sources)
- Histamine receptor antagonist
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
- CYP2J2 INHIBITOR
- KCNH1 MODULATOR
- KCNH2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD3
- DRD2
- HTR2B
- HTR2A
- LMNA
- MAOA
- MAPK1
- MAPK14
- MAPK3
- MC3R
- MC4R
- ABCC2
- MLNR
- MMP1
- MMP9
- MPG
- MUTYH
- NEIL1
- NEIL2
- NPY1R
- NPY2R
- MC5R
- LCK
- NTHL1
- KDR
- HDAC6
- HMGCR
- HRH2
- HRH3
- HRH4
- HSD17B10
- HTR1A
- HTR1B
- HTR1D
- HTR1E
- HTR2C
- HTR3A
- HTR6
- HTR7
- KAT2A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Histamine H1 Receptor Antagonists
- Histamine-1 Receptor Antagonist
- Anti-Allergic Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Histamine H1 Antagonists, Non-Sedating
- Neurotransmitter Agents
ATC classes
- R06A · ANTIHISTAMINES FOR SYSTEMIC USE
Cross-references
Synonyms
- ALLEGRA
- ALLEGRA ALLERGY
- ALLEGRA HIVES
- ALLEGRA-D 12 HOUR ALLERGY AND CONGESTION
- ALLEGRA-D 24 HOUR ALLERGY AND CONGESTION
- Allegra
- CHILDREN'S ALLEGRA ALLERGY
- CHILDREN'S ALLEGRA HIVES
- CHILDREN'S FEXOFENADINE HYDROCHLORIDE ALLERGY
- CHILDREN'S FEXOFENADINE HYDROCHLORIDE HIVES
- FEXOFENADINE HYDROCHLORIDE
- FEXOFENADINE HYDROCHLORIDE ALLERGY
- terfenadine carboxylate
- fexofenadine hydrochloride
- fexofenadine HCl
- Fexofenadina
- Telfast
- Carboxyterfenadine
- Fexofendine
- Terfenadine acid metabolite
- Terfenadine carboxylate
- F 9427
- MDL 16455
- Allegra (TN)
- Fastofen (TN)
- Fexofenadine (INN)
- Fexofenadine [INN:BAN]
- Telfast (TN)
- Terfenadine-COOH
- Terfenidine carboxylate, MDL 16455
- Tilfur (TN)
- fexofenadine (usp-rs)
- E6582LOH6V
- MDL-16455
- CHEBI:5050
- fexofenadinum
- RefChem:5830
- DTXCID50197277
Reported adverse events
- Cough
- Dizziness
- Fatigue
- Headache
- Pain in extremity
- Pain
- Dyspepsia
- Myalgia
- Nasopharyngitis
- Nausea
- Pyrexia
- Somnolence
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