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ZOLPIDEM
SynDRA canonical compound SYN0002525 — structure-anchored drug synonym record
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GABRA3 |
|---|
| Mechanism of action | Benzodiazepine receptor agonist |
|---|
All known targets
- GABRA1
- GABRA2
- GABRA3
- GABRG2
- GABRB1
- ABCB1
- Gabrb2
- RCE1
- Gabrq
- Gabrp
- Gabrg3
- Gabrg2
Mechanisms of action (all sources)
- Benzodiazepine receptor agonist
- GABRA1 POSITIVE ALLOSTERIC MODULATOR
- GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator
- GABRG2 POSITIVE ALLOSTERIC MODULATOR
- GABRB1 POSITIVE ALLOSTERIC MODULATOR
- GABRA2 POSITIVE ALLOSTERIC MODULATOR
- GABRA3 POSITIVE ALLOSTERIC MODULATOR
- GABRG3 MODULATOR (ALLOSTERIC MODULATOR)
- GABRA1 MODULATOR
- GABRA1 ALLOSTERIC MODULATOR
- GABRB2 POSITIVE ALLOSTERIC MODULATOR
- GABRB3 POSITIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- ADRA1A
- CHRM1
- HTR7
- NPY1R
- MLNR
- MC4R
- MC3R
- MAOA
- LMNA
- KDM4E
- KCNH2
- HTR6
- NR1H4
- HTR5A
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HSD17B10
- HRH3
- HRH2
- NPY2R
- ADORA1
- HPGD
- PTGS2
- TBXA2R
- TACR2
- TACR1
- SLCO1B3
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- PRKCE
- NR3C1
- PGR
- PDE6A
- PDE4D
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP1A2
- CP3A4
- CP3A7
- ESRRA
- GBRA2
- GBRA3
- GCR
- PADI4
- RARA
Drug classes
- GABA A Agonists
- Central Nervous System Agents
- Central Nervous System Depressants
- GABA Agents
- GABA Agonists
- GABA-A Receptor Agonists
- Hypnotics and Sedatives
- Neurotransmitter Agents
- Sleep Aids, Pharmaceutical
- gamma-Aminobutyric Acid-ergic Agonist
ATC classes
- N05C · HYPNOTICS AND SEDATIVES
Cross-references
Synonyms
- AMBIEN
- AMBIEN CR
- Ambien
- EDLUAR
- Edluar
- INTERMEZZO
- TOVALT ODT
- ZOLPIDEM TARTRATE
- ZOLPIMIST
- Zolpimist
- ambien
- zolpidem tartrate
- Sanval
- Zolpidem civ
- Zolpidemum
- Lorex
- Zolpidemum [Latin]
- Zolpidem [INN:BAN]
- UNII-7K383OQI23
- CHEMBL911
- DEA No 2783
- CHEBI:10125
- ZAFYATHCZYHLPB-UHFFFAOYSA-N
- 7K383OQI23
- NCGC00095179-01
- SL-800750
- ZolpiMist
- Zolpidem tartrate
- Zolpidem (low-dose oral spray, middle-of-the-night awakenings)
- Zolpidem (low-dose oral spray, middle-of-the-night awakenings), NovaDel
- [3H]zolpidem
- zolpidem civ (usp-rs)
- DTXCID5025946
- Edlular
- Zolpi Lich
- RefChem:6366
- SL 800750 23 N
- N05CF02
Reported adverse events
- Depression
- Headache
- Constipation
- Dizziness
- Rash
- Influenza
- Amnesia
- Lethargy
- Pharyngitis
- Sinusitis
- Abdominal pain
- Abnormal dreams
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