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ORPHENADRINE
SynDRA canonical compound SYN0002461 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP2B6 |
|---|
| Mechanism of action | acetylcholine receptor antagonist |
|---|
| Indication | muscle pain |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SCN10A
- SLC6A2
- SCN9A
- SCN1A
- SCN5A
- SCN4A
- HRH1
- GRIN2D
- SCN11A
- SCN2A
- SCN3A
- GRIN3B
Mechanisms of action (all sources)
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
- SLC6A2 INHIBITOR
- Norepinephrine transporter inhibitor
- SCN1A BLOCKER
- Sodium channel alpha subunit blocker
- SCN5A BLOCKER
- SCN4A BLOCKER
- SCN7A BLOCKER
- SCN2A BLOCKER
- SCN9A BLOCKER
- SCN3A BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SLC22A2
- SLC6A3
- DRD3
- ACHE
- OPRM1
- OPRK1
- OPRD1
- NR3C1
- NPY2R
- NPY1R
- NPSR1
- MMP9
- MMP1
- MC5R
- MC4R
- PDE4A
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KDR
- KDM4E
- KDM4A
- HTR1A
- PDE3A
- PGR
- PDE5A
- HMGCR
- VDR
- THRB
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SMAD3
- SLCO1B3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- ACM4
- ACM5
- CP1A2
- CP2D6
- CP3A7
- GLI3
- JUN
- NR1I2
- PLIN5
- RARA
Drug classes
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Central Nervous System Agents
- Cholinergic Agents
- Cholinergic Antagonists
- Cytochrome P-450 CYP2B6 Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Metabolic Side Effects of Drugs and Substances
- Muscarinic Antagonists
- Muscle Relaxants, Central
- Neuromuscular Agents
ATC classes
- M03B · MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
- N04A · ANTICHOLINERGIC AGENTS
Cross-references
Synonyms
- Biorphen
- DISIPAL
- INVAGESIC
- INVAGESIC FORTE
- NORFLEX
- NORGESIC
- NORGESIC FORTE
- ORPHENADRINE CITRATE
- ORPHENADRINE CITRATE, ASPIRIN, AND CAFFEINE
- ORPHENGESIC
- ORPHENGESIC FORTE
- disipal
- orphenadine
- orphenadrin
- orphenadrine citrate
- orphenadrine hydrochloride
- orphenadrine (chloride)
- orphenadrine HCl
- Orfenadrina
- Mefenamine
- Invagesic
- Mialgin
- Norgesic
- Orphenadrin
- Orphengesic
- Antiflex
- Brocadisipal
- Brocasipal
- Disipal
- Lysantin
- Mephenamine
- Methyldiphenylhydramine
- Myolin
- Myotrol
- ORP
- Orfro
- Orphenadine
- Orphenadinum
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