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DIFLUNISAL
SynDRA canonical compound SYN0002455 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Prostanoid receptor antagonist |
|---|
| Indication | osteoarthritis | rheumatoid arthritis |
|---|
| Disease area | rheumatology |
|---|
All known targets
- PTGS2
- PTGS1
- DHFR
- ACMSD
- CA1
- CA2
- TTR
Mechanisms of action (all sources)
- Prostanoid receptor antagonist
- PTGS2 INHIBITOR
- Cyclooxygenase inhibitor
- PTGS1 INHIBITOR
- dihydrofolate reductase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CXCL12
- SLC22A6
- ALB
- ACHE
- MAPK3
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MDH1
- MC5R
- MC4R
- MC3R
- MAPK14
- OPRK1
- MAPK1
- MAOA
- LMNA
- LCK
- KDM4E
- KCNH2
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HSD17B10
- OPRD1
- PDE3A
- OPRM1
- HRH1
- USP2
- UGT2B7
- UGT2B4
- UGT2B10
- UGT1A9
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2C9
- ESRRA
- HXA9
- KCMB1
- KCMB2
- KCMB4
- NF2L2
- NTM1A
- NTMT1
- PPARG
- S12A5
Drug classes
- Cyclooxygenase Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Sensory System Agents
- Nonsteroidal Anti-inflammatory Drug
ATC classes
- N02B · OTHER ANALGESICS AND ANTIPYRETICS
Cross-references
Synonyms
- DOLOBID
- Dolobid
- difludol
- diflusinal
- fluniget
- fluodonil
- difluorophenylsalicylic acid
- MK-647
- NSC-756728
- Dolobid 500
- Adomal
- Algobid
- Citidol
- Difludol
- Diflunisalum
- Dolisal
- Dolobil
- Dolobis
- Dolocid
- Flovacil
- Fluniget
- Fluodonil
- Flustar
- Noaldol
- Reuflos
- Unisal
- Apotex Brand of Diflunisal
- Cahill May Roberts Brand of Diflunisal
- Diflunisal Novopharm Brand
- Frosst SA Brand of Diflunisal
- Merck Brand of Diflunisal
- Novopharm Brand of Diflunisal
- Nu-Pharm Brand of Diflunisal
- MK647
- Apo-Diflunisal
- Diflunisalum [INN-Latin]
- Dolobid (TN)
Reported adverse events
- Dizziness
- Erythema multiforme
- Headache
- Hypersensitivity
- Hypersensitivity vasculitis
- Rash
- Somnolence
- Thrombocytopenia
- Asthenia
- Stevens-Johnson syndrome
- Vertigo
- Nervousness
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