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PROBENECID
SynDRA canonical compound SYN0002454 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC22A8 |
|---|
| Mechanism of action | Uricosuric blocker |
|---|
| Indication | gout | hyperuricemia |
|---|
| Disease area | nephrology | rheumatology |
|---|
All known targets
- SLC22A8
- SLC22A6
- SLC22A11
- SLCO1C1
- Slc22a20
- Trpv2
- TRPV2
- TAS2R38
- TAS2R16
- Slc22a6
- ABCC1
- CA12
Mechanisms of action (all sources)
- Uricosuric blocker
- SLC22A6 INHIBITOR
- Solute carrier family 22 member 6 inhibitor
- SLC22A8 INHIBITOR
- Solute carrier family 22 member 8 inhibitor
- SLC22A11 INHIBITOR
- Solute carrier family 22 member 11 inhibitor
- TAS2R16 ANTAGONIST
- TAS2R38 ANTAGONIST
- SLCO1C1 INHIBITOR
- SLC22A8 BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- ABCB1
- NR1I2
- MC5R
- MLNR
- MMP1
- MMP9
- NPY1R
- NPY2R
- NR3C1
- MC3R
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- MC4R
- MAPK3
- HDAC6
- MAPK14
- MAPK1
- MAOA
- LCK
- KCNH2
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH2
- HRH1
- PDE5A
- PGR
- PPP3CA
- PRKCA
- VDR
- USP1
- UGT1A9
- UGT1A8
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Adjuvants, Pharmaceutic
- Antirheumatic Agents
- Gout Suppressants
- Pharmaceutic Aids
- Uricosuric Agents
- Mitogens
ATC classes
- M04A · ANTIGOUT PREPARATIONS
Cross-references
Synonyms
- BENEMID
- COL-PROBENECID
- COLBENEMID
- ORLYNVAH
- Orlynvah
- POLYCILLIN-PRB
- PRINCIPEN W/ PROBENECID
- PROBALAN
- PROBAMPACIN
- PROBEN-C
- PROBENECID AND COLCHICINE
- benecid
- probecid
- probenecid acid
- Probenecide
- P-(dipropylsulfamoyl)benzoic acid
- Probenate
- Probenecidum
- HC 5006
- NSC-18786
- Benemid
- Benuryl
- Probalan
- Probampicin
- Probecid
- Probenecid component of col-
- Probenecid component of colbenemid
- Probenecid component of orlynvah
- Probenecid component of probampacin
- Probenecid component of proben-c
- Apurina
- Bencid
- Benecid
- Benemide
- Panuric
- Parabenem
- Probampacin
Reported adverse events
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