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HYDROXYZINE
SynDRA canonical compound SYN0002453 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HRH1 |
|---|
| Mechanism of action | Antihistamine |
|---|
| Indication | anxiety | dermatosis | itching | urticaria |
|---|
| Disease area | allergy | dermatology | neurology/psychiatry |
|---|
All known targets
- HRH1
- CYP2D6
- DRD2
- HTR2A
- env
Mechanisms of action (all sources)
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- HTR7
- ESR1
- HTR2B
- SLCO1B1
- SLCO1B3
- DRD4
- ADRB2
- KCNH2
- ADRA2C
- ADRA2B
- HTR6
- ADRA1A
- HRH2
- HTR5A
- DRD3
- CHRM2
- NEIL2
- OGG1
- NTSR1
- NR3C1
- NPY2R
- NPY1R
- ABCB11
- NEIL1
- MUTYH
- MLNR
- MC4R
- MC3R
- OPRD1
- MAPT
- MAOA
- KDM4A
- HTR3A
- MBD4
- PGR
- OPRM1
- SLC6A2
- USP2
- USP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- IP6K1
- SCN2A
- SCN1A
- RPGF3
- RARA
- PRGR
- PAFA2
- PAFA
- PA1B3
- NR1I2
- MDR1
- IFNG
- ACM1
- GLI3
- G3P
- ESRRA
- CP3A7
- CP2D6
- CP2C9
- CASP7
- CASP3
- ANDR
- ACM4
- SCN3A
Drug classes
- Histamine Receptor Antagonists
- Antipruritics
- Dermatologic Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Neurotransmitter Agents
- Antihistamine
ATC classes
Cross-references
Synonyms
- ATARAX
- HY-PAM "25"
- HYDROXYZINE HYDROCHLORIDE
- HYDROXYZINE PAMOATE
- ORGATRAX
- VISTARIL
- Vistaril
- hydroxyzine pamoate
- hydroxizine
- hydroxyzin
- hydroxyzyne
- tranquizine
- hydroxyzine hydrochloride
- hydroxyzine dihydrochloride
- hydroxyzine HCl
- Hidroxizina
- Ataraxoid
- Marex
- Tran-q
- Tranquizine
- U.c.b-4492
- NSC-169188
- Atara
- Atarax
- Atarazoid
- Atarox
- Atazina
- Aterax
- Deinait
- Durrax
- Hychotine
- Hydroksyzyny
- Hydroxine
- Hydroxizine
- Hydroxizinum
- Hydroxycine
- Hydroxyzin
Reported adverse events
- Dry mouth
- Hallucination
- Headache
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