← SynDRA
NALBUPHINE
SynDRA canonical compound SYN0002449 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | OPRM1 |
|---|
| Mechanism of action | Opioid receptor antagonist |
|---|
| Indication | pain relief |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
Mechanisms of action (all sources)
- Opioid receptor agonist
- Opioid receptor antagonist
- OPRK1 AGONIST
- Opioid receptors; mu/kappa/delta agonist
- OPRD1 AGONIST
- OPRM1 AGONIST
- OPRK1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- LCK
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- KCNH2
- ESR2
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HRH2
- HRH1
- HMGCR
- GLS
- FYN
- NPY1R
- NPY2R
- NR3C1
- PDE5A
- USP1
- UGT2B7
- TST
- TBXAS1
- TACR2
- TACR1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SIGMAR1
- SAMHD1
- PTPRC
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ABL1
- KAPCB
- KIFAP3
- MDR1
- RIN1
Drug classes
- Analgesics
- Analgesics, Opioid
- Central Nervous System Agents
- Central Nervous System Depressants
- Narcotics
- Peripheral Nervous System Agents
- Sensory System Agents
- Partial Opioid Agonists
- Competitive Opioid Antagonists
- Opioid Agonist/Antagonist
ATC classes
Cross-references
Synonyms
- NALBUPHINE HYDROCHLORIDE
- NUBAIN
- N-Cyclobutylmethyl-14-hydroxydihydronormorphine
- nalbuphine hydrochloride
- nalbuphine HCl
- Nalbufina
- Intapan
- Nalbuphinum
- Intapan (TN)
- Nalbuphine (INN)
- Nubain (TN)
- PHN-131
- Nalbuphine HCL
- Nubain
- Nalbufina clorhidrato [Spanish]
- Nalbuphine hydrochloride [USAN]
- EN-2234A
- UNII-ZU4275277R
- EINECS 245-549-9
- ZU4275277R
- N-Cyclobutylmethyl-14-hydroxydihydronormorphine hydrochloride
- Nalbuphine h
- Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-
- L2T84IQI2K
- N-Cyclobutylmethyl-4,5alpha-epoxy-3,6alpha,14-morphinantriol
- CHEBI:7454
- DTXCID103345
- RefChem:57230
- NALBUPHINE [INN]
- Nalbuphine (1.0mg/ml in Acetonitrile)
- Nalbufina [DCIT]
- Nalbuphine [INN:BAN]
- Nalbuphinum [INN-Latin]
- UNII-L2T84IQI2K
- NCGC00162275-02
- EINECS 243-901-6
- NALBUPHINE [MI]
Reported adverse events
- Depression
- Se
- Death
- Hypertension
- Nervousness
- Abdominal pain
- Allodynia
- Adrenal insufficiency
- Serotonin syndrome
- Overdose
Look up NALBUPHINE in the interactive SynDRA portal →