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BUPROPION
SynDRA canonical compound SYN0002447 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC6A3 |
|---|
| Mechanism of action | Dopamine uptake inhibitor |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A2
- SLC6A3
- SLC6A4
- ADRA1A
- CHRNA3
- CHRNA7
- CHRNB2
- CHRNB4
- CYP2B6
- CYP2C19
- CYP2D6
- Pgrmc1
Mechanisms of action (all sources)
- Dopamine uptake inhibitor
- SLC6A3 INHIBITOR
- Dopamine transporter inhibitor
- SLC6A2 INHIBITOR
- Norepinephrine transporter inhibitor
- dopamine reuptake inhibitor
- SLC6A4 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- CHRNA4
- ABCC2
- KCNH2
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MBNL1
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KAT2A
- NPY2R
- HTR7
- HTR6
- HTR5A
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GMNN
- NPY1R
- NR3C1
- GHSR
- NTSR1
- USP1
- TDP1
- TBXAS1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CHRNA1
- CHRNB1
- CHRND
- CHRNG
- CP2CJ
- CP2D6
- GLI3
- ITGA5
- JUN
- MDR1
- S12A5
Drug classes
- Norepinephrine Uptake Inhibitors
- Dopamine Uptake Inhibitors
- Aminoketone
- Antidepressive Agents
- Antidepressive Agents, Second-Generation
- Central Nervous System Agents
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Dopamine Agents
- Enzyme Inhibitors
- Membrane Transport Modulators
- Metabolic Side Effects of Drugs and Substances
ATC classes
- N06A · ANTIDEPRESSANTS
- ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
Cross-references
Synonyms
- APLENZIN
- AUVELITY
- Aplenzin
- Auvelity
- BUPROPION HYDROCHLORIDE
- CONTRAVE
- FORFIVO XL
- Forfivo
- WELLBUTRIN
- WELLBUTRIN SR
- WELLBUTRIN XL
- Wellbutrin
- (+/-)-Bupropion
- amfebutamon
- amfebutamone
- aplenzin
- elontril
- bupropion hydrochloride
- bupropion hydrobromide
- bupropion HCl
- wellbutrin
- Bupropione
- Amfebutamone
- Bupropion extended release
- Bupropion slow release
- NSC-758686
- Amfebutamon
- 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one
- amfebutamonum
- Amfebutamona
- (+-)-Bupropion
- Wellbatrin
- Bupropion [INN:BAN]
- Elontril
- Amfebutamonum [INN-Latin]
- Zyban
- Amfebutamona [INN-Spanish]
- Bupropion SR
Reported adverse events
- Depression
- Depressed mood
- Anxiety
- Constipation
- Dizziness
- Hypertension
- Nausea
- Palpitations
- Pruritus
- Rash
- Tremor
- Insomnia
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