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PD-0166285
SynDRA canonical compound SYN0002414 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | EGFR | FGFR1 | PDGFRB | PKMYT1 | SRC | WEE1 |
|---|
| Mechanism of action | SRC inhibitor |
|---|
All known targets
- SRC
- EGFR
- FGFR1
- PDGFRB
- PKMYT1
- WEE1
Mechanisms of action (all sources)
- EGFR INHIBITOR
- Epidermal growth factor receptor erbB1 inhibitor
- FGFR1 INHIBITOR
- Fibroblast growth factor receptor 1 inhibitor
- PDGFRB INHIBITOR
- Platelet-derived growth factor receptor beta inhibitor
- SRC inhibitor
- Tyrosine-protein kinase SRC inhibitor
- PKMYT1 INHIBITOR
- WEE1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- WEE2
- NOD2
- ACVR1
- CHEK1
- CDK1
- SLC2A1
- RIPK2
- MYT1
- PDGFRA
- PAK4
- NTRK3
- NTRK2
- NTRK1
- MST1R
- PKN2
- MINK1
- MET
- MAPK9
- MAPK8
- MAPK14
- MAP4K5
- PIM1
- PRKCQ
- PRKAA1
- PRKACA
- TYRO3
- TNK2
- TBK1
- TAOK1
- SYK
- STK3
- STK17A
- RPS6KA3
- ROCK2
- ROCK1
- RET
- PTK2
- PRKX
- PRKD3
- MAP4K2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AAPK1
- PMYT1
- MP2K2
- NSD2
- NTM1A
- NTMT1
- PARP1
- PGFRA
- SNCA
- ATXN2
- ST17A
- SYUA
- TFE3
- TP53
- VGFR1
- VGFR2
- MP2K1
- MK14
- MK09
- MK08
- MITF
- M4K5
- M4K4
- M4K2
- KSYK
- KS6A3
- KPCD3
- KAPCA
- IFNB1
- HLAB
- FGFR4
- FGFR3
- FGFR2
- YES1
Cross-references
Synonyms
- PD-166285
- PD166285
- TCMDC-140940
- PD0166285
- CHEMBL49120
- 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one
- 6-(2,6-Dichlorophenyl)-2-({4-[2-(Diethylamino)ethoxy]phenyl}amino)-8-Methylpyrido[2,3-D]pyrimidin-7(8h)-One
- IFPPYSWJNWHOLQ-UHFFFAOYSA-N
- AC1NSKIX
- Kinome_3263
- SCHEMBL133914
- BDBM3096
- GTPL8183
- MolPort-044-560-325
- ZINC1486219
- BCP20228
- s8148
- AKOS032945173
- NCGC00242490-02
- NCGC00242490-01
- HY-13925
- CS-0008610
- PD 166285
- PD 0166285
- F2UH9R2JT6
- RefChem:1073669
- C26H27Cl2N5O2
- orb1300335
- SCHEMBL30250248
- EX-A4179
- KHA03989
- WZB81459
- CCG-269785
- EBC-114024
- NCGC00242490-08
- AC-35457
- BS-16163
- DA-76653
- PD0166285?
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