← SynDRA

2-METHOXYESTRADIOL

SynDRA canonical compound SYN0002393 — structure-anchored drug synonym record

All known targets

• HIF1A
• CASP3
• COMT
• CYP19A1
• CYP1A1
• CYP1B1
• GPER1
• TNFRSF10B
• TUBB

Mechanisms of action (all sources)

• GPER1 AGONIST
• hypoxia inducible factor inhibitor
• HIF1A MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• APOBEC3G
• ATAD5
• TDP1
• TARDBP
• SLC22A1
• SHBG
• RGS4
• PMP22
• NFE2L2
• MTOR
• MPHOSPH8
• MAPT
• LMNA
• IDH1
• HDAC6
• GMNN
• GLP1R
• GBA1
• GAA
• ESR2
• ESR1
• EHMT2
• CBX1
• BLM
• ATXN2
• UGT2B7

Cross-references

• PubChem CID: 66414
• ChEMBL: CHEMBL299613
• DrugBank: DB02342
• ChEBI: 28955
• KEGG: C05302
• PDB: ESM
• Wikipedia: 2-Methoxyestradiol
• TTD: D06NYA
• LINCS BRD: BRD-K44408410

Synonyms

• 2-methoxyoestradiol
• NSC-659853
• ESM
• Panzem
• PulmoLAR
• Panzem NCD
• M 6383
• (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
• (17beta)-2-methoxyestra-1(10),2,4-triene-3,17-diol
• (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER
• 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether
• 2,3,17beta-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether
• 2-Hydroxyestradiol 2-methyl ether
• 2-Hydroxyestradol 2-methyl ether
• 2-ME2, 2-Methoxyestradiol
• 2-Methoxyestra-1,3,5(10)-triene-3,17beta-diol
• 2-Methoxyestradiol-17beta
• 3,17beta-Dihydroxy-2-methoxy-1,3,5(10)-estratriene
• BRD-K44408410
• 2-ME2
• 2ME2
• 2-Methoxy 17beta-Estradiol
• 2 Methoxyoestradiol
• NSC 659853
• 6I2QW73SR5
• Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17beta)-
• 2-methoxy-estra-1,3,5(10)-triene-3,17beta-diol
• CHEBI:28955
• 2 Methoxyestradiol 17 beta
• RefChem:388747
• DTXCID1020938
• (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol
• 2-Methoxyestradiol (2-MeOE2)
• Estradiol, 2-methoxy-
• 2-Methoxy-beta-estradiol
• MFCD00010489
• 2-methoxy Estradiol