INDIBULIN

SynDRA canonical compound SYN0002365 — structure-anchored drug synonym record

Clinical phase	Phase 1/Phase 2
Mechanism of action	tubulin polymerization inhibitor

All known targets

TUBA1A
TUBA1B
TUBA1C
TUBA3C
TUBA3E
TUBA4A
TUBB
TUBB1
TUBB2A
TUBB2B
TUBB3
TUBB4A

Mechanisms of action (all sources)

TUBB4B INHIBITOR
TUBB1 INHIBITOR
TUBA3C INHIBITOR
TUBA4A INHIBITOR
TUBB3 INHIBITOR
TUBA1A INHIBITOR
TUBB4A INHIBITOR
TUBB8 INHIBITOR
TUBB INHIBITOR
TUBA1B INHIBITOR
TUBA1C INHIBITOR
TUBA3E INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

HDAC6

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

CP2C9
CP3A7
TUBB8
TUBB6
TUBB4B
TUBB4A
TUBB3
TUBB2B
TUBB2A
TUBB1
TUBB
TUBA4A
TUBA3E
TUBA3C
TUBA1C
TUBA1B
TUBA1A
TFE3
SYK
NSD2
MITF
KSYK
IFNG
YAP1

Cross-references

PubChem CID: 2929
ChEMBL: CHEMBL49642
DrugBank: DB06169
KEGG: D10013
TTD: D04NXL
LINCS BRD: BRD-K74057757

Synonyms

Indibuline
Indibulina
D-24851
ZIO-301
2-(1-(4-chlorobenzyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
D 24851
UNII-80K4H2RB8P
80K4H2RB8P
2-[1-(4-chlorobenzyl)-1h-indol-3-yl]-2-oxo-n-(pyridin-4-yl)acetamide
N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]-glyoxyl Amide
Indibulin [USAN:INN]
2-{1-[(4-chlorophenyl)methyl]indol-3-yl}-2-oxo-N-(4-pyridyl)acetamide
2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-(4-pyridyl)acetamide
Indibulin (USAN/INN)
AC1L1ESK
AC1Q5NS8
MLS006011745
CHEMBL49642
ZIO 301
ZIO 301;D 24851
2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
Indibulin [INN]
1H-Indole-3-acetamide, 1-((4-chlorophenyl)methyl)-alpha-oxo-N-4-pyridinyl-
1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-alpha-oxo-N-4-pyridinyl-
INDIBULIN [USAN]
SCHEMBL3165856
DTXSID70174368
AMY21420
BCP33949
EX-A4542
BDBM50510963
MFCD05861105
NSC758489
STK783524
ZINC37866151
AKOS005619980
D 24851ZIO 301

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