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ALENDRONIC ACID
SynDRA canonical compound SYN0002348 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTPRS |
|---|
| Mechanism of action | Bone resorption inhibitor |
|---|
| Indication | osteoporosis |
|---|
| Disease area | orthopedics |
|---|
All known targets
- FDPS
- PTPRS
- ATP6V1A
- FNTB
- FPPS
- Fdps
- Idi1
- PTPN4
- PTPRE
Mechanisms of action (all sources)
- Bone resorption inhibitor
- FDPS INHIBITOR
- Farnesyl diphosphate synthase inhibitor
- FDPS MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PDE3A
- ACHE
- KCNH2
- MMP3
- MMP2
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- HTR7
- NPY1R
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GIPR
- GHSR
- MMP9
- NPY2R
- GABBR1
- PTPN1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A4
- SLC6A3
Drug classes
- Bisphosphonate
- Bone Density Conservation Agents
ATC classes
- M05B · DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Cross-references
Synonyms
- ALENDRONATE SODIUM
- BINOSTO
- Binosto
- FOSAMAX
- FOSAMAX PLUS D
- Fosamax
- Fosamax Plus D
- alendronate monosodium salt trihydrate
- alendronate sodium trihydrate
- alendronate sodium hydrate
- alendronate
- alendronate sodium
- aminohydroxybutane bisphosphonate
- MK-217
- Acide alendronique
- Acido alendronico
- Alendronate
- Arendal
- Acidum alendronicum
- Acide alendronique [INN-French]
- Acido alendronico [INN-Spanish]
- Acidum alendronicum [INN-Latin]
- Alendronic acid (INN)
- Alendronic acid [INN:BAN]
- Bisphosphonate, 65
- Fosamax (TN)
- Phosphonic acid, (4-amino-1-hydroxybutylidene)bis
- (4-Amino-1-hydroxybutylidene)bisphosphonic acid
- (4-Amino-1-hydroxybutylidene)diphosphonic acid
- 4-Amino-1-hydroxybutane-1,1-diphosphonate
- 4-Amino-1-hydroxybutane-1,1-diphosphonic Acid
- 4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid)
- 4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
- alendronic-acid
- alpha-hydroxy-delta-aminobutylidenediphosphonic acid
- Phosphonic acid, P,P'-(4-amino-1-hydroxybutylidene)bis-
- ABDP
Reported adverse events
- Fracture
- Rash
- Stevens-Johnson syndrome
- Headache
- Abdominal pain
- Constipation
- Dizziness
- Dyspepsia
- Flatulence
- Gastritis
- Vomiting
- Nausea
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