PHLORETIN

SynDRA canonical compound SYN0002332 — structure-anchored drug synonym record

Clinical phase	Launched
Primary target(s)	AQP9 \| CLCN3 \| SLC23A1
Mechanism of action	sodium/glucose cotransporter inhibitor

All known targets

AQP9
CLCN3
SLC23A1
TAS2R14
TAS2R39

Mechanisms of action (all sources)

AQP9 MODULATOR
CLCN3 MODULATOR
TAS2R14 AGONIST
TAS2R39 AGONIST
SLC23A1 INHIBITOR
sodium/glucose cotransporter inhibitor
AQP9 INHIBITOR
CLCN3 BLOCKER (CHANNEL BLOCKER)

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

5HT2A
IP6K1
SMAD2
S23A1
PRGR
PPARG
PIP4K2A
PHGDH
PA1B2
NF2L2
LYAG
GSTO1
ACES
GLI3
ESR2
DPOLB
CP3A4
CP2CJ
CP2C9
CP1A2
ANDR
ALAT2
STK33

Cross-references

PubChem CID: 4788
ChEMBL: CHEMBL45068
DrugBank: DB07810
ChEBI: 17276
KEGG: C00774
RxNorm: 1368167
PDB: G50
Wikipedia: Phloretin
TTD: D0HD2G
LINCS BRD: BRD-K15563106

Synonyms

3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
Dihydronaringenin
Phloretol
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
NSC 407292
UNII-S5J5OE47MK
1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-
CCRIS 7459
beta-(p-Hydroxyphenyl)phloropropiophenone
2',4',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone
2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone
EINECS 200-488-7
NSC407292
S5J5OE47MK
beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone
DTXCID702393
FEMA NO. 4390
CHEBI:17276
2',4,4',6'-Tetrahydroxydihydrochalcone
2',4,4',6'-Tetrahydroxy-Dihydrochalcone
RefChem:861869
MFCD00002288
Phloretin (Standard)
2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)-propiophenone
4,2',4',6'-Tetrahydroxydihydrochalcone
beta-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone
Propiophenone, 2',4',6'-trihydroxy-3-(p-hydroxyphenyl)-
.beta.-(p-Hydroxyphenyl)phloropropiophenone
NSC 407292;RJC 02792
SMR000326783
SR-01000076081
Asebogenol;
Dihydronarigenin;
2uxi
G50
Icaritin Impurity 7
Spectrum_001295

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