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OMACETAXINE MEPESUCCINATE
SynDRA canonical compound SYN0002329 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | RPL3 |
|---|
| Mechanism of action | protein synthesis inhibitor |
|---|
| Indication | chronic myeloid leukemia (CML) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
Mechanisms of action (all sources)
- protein synthesis inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- ADORA1
- SLC6A4
- SLC6A3
- SLC6A2
- PTGS1
- PGR
- PDE4A
- PDE3A
- OPRM1
- MAOA
- KCNH2
- HTR2B
- HTR1A
- HRH3
- HDAC6
- F2
- ESR1
- DRD3
- DRD1
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP3A4
- HLAB
- HTT
- IFNB1
- IFNG
- PARP1
- YAP1
Drug classes
- Antineoplastic Agents
- Antineoplastic Agents, Phytogenic
- Enzyme Inhibitors
- Protein Synthesis Inhibitors
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- SYNRIBO
- Synribo
- synribo
- homoharringtonine
- CGX-635
- NSC-141633
- Mepesuccinate d'omacetaxine
- Mepesuccinato de omacetaxina
- Ceflatonin
- Homoharringtonin
- Myelostat
- Omapro
- HOMOHARRINGTONINE
- Synribo (TN)
- BRD-K76674262
- (-)-homoharringtonine
- NSC 141633
- C29H39NO9
- CHEBI:71019
- (2'R,3S,4S,5R)-(-)-homoharringtonine
- Omacetaxine (homoharringtonine)
- Omacetaxine mepesuccinate [USAN]
- 6FG8041S5B
- Omacetaxine mepesuccinate (USAN)
- Tekinex
- UNII-6FG8041S5B
- NSC141633
- NCGC00025155-01
- Omacetaxine mepesuccinate [USAN:INN]
- BRN 5687925
- omacetaxini mepesuccinas
- ZJ-C
- mepesuccinate d'omacetaxine
- mepesuccinato de omacetaxina
- MLS001424293
- CHEMBL46286
- HOMOHARRINGTONINE [MI]
- CGX-635-14 (formulation)
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