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BERBERINE
SynDRA canonical compound SYN0002269 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | LDLR |
|---|
| Mechanism of action | LDL receptor activator |
|---|
All known targets
- LDLR
- ACHE
- CYP1B1
- CYP2C19
- CYP2D6
- CYP2E1
- PTPN1
- TERT
Mechanisms of action (all sources)
- LDL receptor activator
- CYP1B1 INHIBITOR
- CYP2D6 INHIBITOR
- TERT INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- IDO1
- AKR1C2
- NEK7
- CHRM1
- EP300
- ESR1
- SIGMAR1
- SLC47A1
- SLC47A2
- BCHE
- AKR1C3
- PPARA
- KDM1A
- ADRA2C
- ADRA2B
- TDO2
- KCNH2
- HTR2B
- MT-CO2
- P2RX7
- OPRM1
- OPRK1
- OPRD1
- NR3C1
- NPY2R
- NPY1R
- NFKB1
- NFE2L2
- MAPK14
- MMP9
- MAPK1
- MMP1
- LCK
- PDE5A
- LMNA
- MC4R
- MC3R
- MBNL1
- MAPT
- MAPK3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- GLI3
- UHRF1
- TP53
- SYK
- STK33
- SMAD3
- SMAD2
- NSD2
- NF2L2
- MDR1
- KSYK
- HCRTR1
- G3P
- ACM4
- ESRRA
- CREB1
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP1A2
- COT2
- ATRX
- ANDR
- AHR
- YAP1
Cross-references
Synonyms
- Berbericine
- Berberin
- Berberone
- Majarine
- Thalsine
- Umbellatin
- Umbellatine
- UNII-0I8Y3P32UF
- 0I8Y3P32UF
- CHEBI:16118
- EINECS 218-229-1
- Berberal
- BRN 3570374
- ST055798
- 9,10-Dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbinium
- Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-
- 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium
- Berbamine sulphate acid
- CHEMBL12089
- 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium
- BERBINIUM, 7,8,13,13a-TETRAHYDRO-9,10-DIMETHOXY-2,3-(METHYLE
- 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene
- Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-
- Berberine hydrogen sulfate
- 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
- 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo-[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium
- GNF-PF-4545
- BER
- NSC646666
- NCGC00016526-02
- NCGC00016526-07
- CAS-633-65-8
- Berbinium
- berberine dimer
- Coptis rhizome
- C20H18NO4
- 5,6-DIHYDRO-9,10-DIMETHOXYBENZO(G)-1,3-BENZODIOXOLO(5,6-A)QUINOLIZINIUM
- 9,10-DIMETHOXY-5,6-DIHYDRO(1,3)DIOXOLO(4,5-G)ISOQUINO(3,2-A)ISOQUINOLIN-7-IUM
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