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FLUSPIRILENE
SynDRA canonical compound SYN0002255 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | HTR2A |
|---|
| Mechanism of action | Dopamine receptor antagonist |
|---|
| Indication | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- HTR2A
- HRH1
- HTR1A
- HTR1E
- HTR1D
- KCNH2
- HTR6
- HTR2B
- HTR1B
- ADRA2A
- ADRA2B
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- DRD2 INHIBITOR
- Dopamine D2 receptor inhibitor
- HTR1A ANTAGONIST
- HTR1D ANTAGONIST
- HTR1E ANTAGONIST
- HTR2A ANTAGONIST
- HRH1 ANTAGONIST
- DRD2 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- SLC6A2
- CACNA1C
- SLC6A4
- GHSR
- CHRM3
- OPRD1
- SLC6A3
- ESR1
- MLNR
- OPRM1
- MC3R
- ADRA1A
- ADORA3
- NR3C1
- NR1I2
- ADORA1
- NPY1R
- PDE4D
- NPSR1
- NPC1
- NFKB1
- NFE2L2
- MTOR
- MPHOSPH8
- MC4R
- PDE3A
- POLK
- PGR
- PIN1
- VDR
- USP2
- USP1
- TP53
- THPO
- TDP1
- TBXA2R
- SMPD1
- SMN1
- SMAD3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- IFNG
- M4K2
- MDM2
- MDM4
- MLP3A
- NSD2
- NTR1
- OPRD
- OPRM
- PPARD
- PPARG
- PPP1CA
- PRGR
- RARA
- STK33
- TAAR1
- KCNK2
- IFNB1
- 5HT1D
- IDHC
- 5HT1E
- 5HT2A
- ANDR
- APAF
- BARD1
- BRCA1
- CP1A2
- CP2C9
- CP2D6
- ESR2
- ESRRA
- GEMI
- GNA15
- GPR151
- HCRTR1
- TPO
Drug classes
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Neurotransmitter Agents
- Psychotropic Drugs
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- fluspirilen
- fluspiriline
- redeptin
- R-6218
- Fluspirileno
- MCN-JR-6218
- Imap
- Redeptin
- Fluspirilen
- Fluspirilenum
- Spirodiflamine
- R 6218
- F-100
- Fluspirileno [INN-Spanish]
- Fluspirilenum [INN-Latin]
- Imap (TN)
- Spiropiperidine analogue, 1
- Fluspirilene (USAN/INN)
- Fluspirilene [USAN:INN:BAN]
- McN-JR-6218
- 1-Phenyl-4-oxo-8-(4,4-bis(4-fluorophenyl)butyl)-1,3,8-triazaspiro(4,5)decane
- 8-(4,4-Bis(p-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro-(4.5)decan-4-one
- 8-[4,4-bis (p-fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4,5]decan-4-one
- 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
- 8-[4,4-bis(4-fluorophenyl)butyl]-4-phenyl-2,4,8-triazaspiro[4.5]decan-1-one
- 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one
- McN-JR 6218
- C5QA4GLR9M
- DTXCID5025152
- Beta, Fluspirilen
- RefChem:388987
- N05AG01
- Fluspiriline
- R 6218;Redeptin
- NCGC00015424-04
- NCGC00015424-11
- CAS-1841-19-6
- SMR000058304
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