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GUANFACINE
SynDRA canonical compound SYN0002247 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRA2B |
|---|
| Mechanism of action | Adrenergic receptor agonist |
|---|
| Indication | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- ADRA2A
- ADRA2B
- ADRA2C
- ADRA1D
- Adra1a
- CYP3A5
- HCN1
- HCN2
- HCN3
- HCN4
- HTR2A
- HTR2B
Mechanisms of action (all sources)
- Adrenergic receptor agonist
- ADRA2A AGONIST
- Adrenergic receptor alpha-2 agonist
- ADRA2C AGONIST
- ADRA2B AGONIST
- TADA2A AGONIST
- ADRA2A PARTIAL AGONIST
- ADRA2B FULL AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- HTR1A
- POU2F1
- MAOA
- ACHE
- MPG
- MC5R
- MLNR
- MMP1
- MMP9
- MUTYH
- MC3R
- NEIL1
- NEIL2
- NFE2L2
- NPY1R
- NPY2R
- MC4R
- MBD4
- NR3C1
- MAPT
- MAPK3
- MAPK14
- MAPK1
- LMNA
- LCK
- KCNH2
- IDH1
- HTR6
- HTR3A
- HSD17B10
- HRH2
- HRH1
- NR1I2
- NTHL1
- HIF1A
- S1PR1
- TDP1
- TDG
- TBXAS1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- MDR1
Drug classes
- Adrenergic alpha2-Agonists
- Central alpha-2 Adrenergic Agonist
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-2 Receptor Agonists
- Adrenergic alpha-Agonists
- Antihypertensive Agents
- Cardiovascular Agents
- Neurotransmitter Agents
ATC classes
- C02A · ANTIADRENERGIC AGENTS, CENTRALLY ACTING
Cross-references
Synonyms
- GUANFACINE HYDROCHLORIDE
- INTUNIV
- Intuniv
- TENEX
- guanfacine hydrochloride
- guanfacine HCl
- guanfacine monohydrochloride
- Guanfacina
- NSC-759121
- 30OMY4G3MK
- A902647
- A918619
- AB01563079_01
- AKOS030255657
- AKOS030526130
- BCP09647
- BDBM81984
- Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-
- BPBio1_000415
- BRD-K32830106-003-03-0
- BRD-K32830106-003-11-3
- BSPBio_000377
- C02AC02
- C07037
- CAS_29110-47-2
- CAS-29110-48-3
- CCG-204609
- CHEBI:5558
- CHEMBL862
- D08031
- DB01018
- DTXCID7026944
- DTXSID9046944
- EINECS 249-442-8
- EN300-243924
- Estulic
- Estulic (Salt/Mix)
Reported adverse events
- Asthenia
- Constipation
- Dizziness
- Fatigue
- Headache
- Insomnia
- Somnolence
- Adverse reaction
- Dry mouth
- Eye disorder
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