← SynDRA

E-DOXEPIN

SynDRA canonical compound SYN0002244 — structure-anchored drug synonym record

All known targets

• HRH1
• HRH2
• SLC6A2
• SLC6A4

Mechanisms of action (all sources)

• Histamine receptor antagonist
• HRH1 INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ALDH1A1
• DRD1
• TSHR
• TDP1
• SAMHD1
• RET
• NFKB1
• LMNA
• HTR2B
• CYP3A4
• ALOX15B
• CYP2D6
• CYP2C9
• CYP2C19
• CYP1A2
• CHRM1
• CACNA1B
• ATXN2
• VDR

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• 5HT2A
• ACM1
• ACM4
• ACM5
• CP2D6
• DRD2
• DRD3
• GLI3
• GLP1R
• JUN
• KCMB1
• KCMB2
• KCNH2
• MDR1
• RARA
• RGS4

Cross-references

• PubChem CID: 667477
• ChEMBL: CHEMBL860
• ChEBI: 4711
• KEGG: C06971
• RxNorm: 203179
• PDB: 5EH
• Wikipedia: Doxepin
• TTD: D06FES
• LINCS BRD: BRD-K54462405

Synonyms

• DOXEPIN HYDROCHLORIDE
• SILENOR
• SINEQUAN
• Silenor
• ZONALON
• Zonalon
• doxepin
• (e)-doxepin
• trans-doxepin
• Doxepin, (E)-
• Doxepinum [INN-Latin]
• Doxepina [INN-Spanish]
• sinequan
• Sinequan (TN)
• Doxepin [USAN]
• Doxepine hydrochloride
• MF 10
• Doxepin (INN)
• [11C]doxepin
• [11C]-doxepin
• CCRIS 9176
• HSDB 3069
• Doxepin [INN:BAN]
• NCGC00015344-03
• UNII-5ASJ6HUZ7D
• CAS-1229-29-4
• UNII-851NLB57HQ
• Deptran
• NSC-108160
• Tocris-0508
• Prestwick2_000263
• Prestwick3_000263
• DOXEPIN, E-ISOMER
• Lopac-D-4526
• Doxepin [USAN:INN:BAN]
• Lopac0_000339
• BSPBio_000106
• SCHEMBL116895
• BPBio1_000118