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BAZEDOXIFENE
SynDRA canonical compound SYN0002231 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ESR1 |
|---|
| Mechanism of action | Selective estrogen receptor modulator |
|---|
| Indication | menopause | osteoporosis |
|---|
| Disease area | endocrinology | orthopedics |
|---|
All known targets
Mechanisms of action (all sources)
- Selective estrogen receptor modulator
- ESR2 MODULATOR
- ESR1 MODULATOR
- ESR1 ANTAGONIST
- ESR2 ANTAGONIST
- selective estrogen receptor modulator (SERM)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- ABCB11
- OPRM1
- HTR2C
- HTR3A
- IL11
- IL11RA
- IL6ST
- KCNH2
- MAOA
- MC3R
- MLNR
- NR3C1
- OPRD1
- PDE3A
- ADORA1
- PDE4D
- PGR
- PPARG
- PTGS2
- SCN5A
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- TDP1
- UGT1A1
- UGT1A10
- HTR2B
- HTR2A
- HTR1A
- HRH3
- ADORA2A
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- CP3A7
- TP53
- SYK
- RARA
- PRGR
- PPARD
- KSYK
- GLI3
- GCR
- CP3A4
- ACM1
- CP2D6
- CP2CJ
- CP2C9
- CP19A
- CASP7
- CASP3
- ATXN2
- ALAT2
- TSHR
Drug classes
- Selective Estrogen Receptor Modulators
- Bone Density Conservation Agents
- Estrogen Receptor Modulators
- Hormone Antagonists
- Estrogen Agonist/Antagonist
ATC classes
- G03X · OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
- ESTROGENS
Cross-references
Synonyms
- DUAVEE
- Duavee
- TSE424
- TSE-424
- bazedoxifene acetate
- conbriza
- Bazedoxifeno
- Bazedoxifene component of ak-r215
- Brilence
- Conbriza
- Viviant
- Bazedoxifene acetate
- WAY-140424
- WAY-TES 424
- Q16TT9C5BK
- bazedoxifenum
- RefChem:116748
- DTXCID3096084
- G03XC02
- Bazedoxifene [INN]
- C30H34N2O3
- Bazedoxifene free base
- UNII-Q16TT9C5BK
- Bazedoxifeno [INN-Spanish]
- Bazedoxifene?
- MFCD05148441
- Bazedoxifene (Standard)
- BAZEDOXIFENE [MI]
- BAZEDOXIFENE [VANDF]
- SCHEMBL41935
- orb341885
- BAZEDOXIFENE [WHO-DD]
- GTPL7355
- orb3027356
- BAZEDOXIFENE [EMA EPAR]
- SCHEMBL29370682
- HY-A0031R
- CHEBI:135947
Reported adverse events
- DVT
- Muscle spasms
- Abdominal pain
- Nausea
- Abdominal pain upper
- Dizziness
- Dyspepsia
- Neck pain
- Oropharyngeal pain
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