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ASTEMIZOLE
SynDRA canonical compound SYN0002230 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Primary target(s) | KCNH2 |
|---|
| Mechanism of action | Histamine receptor antagonist |
|---|
All known targets
- HRH1
- KCNH2
- KCNH1
- MC4R
- HRH2
- HRH4
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- HTR6
Mechanisms of action (all sources)
- Histamine receptor antagonist
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
- KCNH1 MODULATOR
- KCNH2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- GHSR
- SCN5A
- MLNR
- CACNA1C
- ESR1
- ESR2
- HTR5A
- ADRB2
- HTR7
- USP7
- MMP1
- PDE4A
- PDE3A
- NTSR1
- NR3C1
- NPY2R
- NPY1R
- NFE2L2
- MMP9
- IDH1
- KDR
- MAPT
- PDE5A
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- HTT
- PDE4D
- PRKCA
- PGR
- SMN1
- USP2
- USP1
- UBE2N
- TP53
- TDP1
- TBXAS1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- NSD2
- IL1B
- ITA4
- JAK2
- KSYK
- M4K2
- MDM2
- MDM4
- MDR1
- MITF
- MMP14
- OXYR
- IDHC
- PAX8
- PPARD
- PPARG
- PRGR
- RARA
- SMAD2
- STK33
- SYK
- TAAR1
- TSHR
- IFNG
- GPR32
- ACES
- CASP3
- ACM1
- ANDR
- APAF
- APLNR
- BARD1
- BRCA1
- CAC1H
- CACNA1D
- CACNA1F
- CACNA1S
- CASP7
- GPR151
Drug classes
- Anti-Allergic Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Histamine H1 Antagonists, Non-Sedating
- Neurotransmitter Agents
ATC classes
- R06A · ANTIHISTAMINES FOR SYSTEMIC USE
Cross-references
Synonyms
- R 43 512
- astemisan
- hismanal
- histazol
- Astemizol
- GNF-Pf-2461
- NSC-329963
- NSC-759570
- R 43,512
- Hismanal
- Pollon-eze
- Alermizol
- Astemina
- Astemisan
- Astemisol
- Astemison
- Astemizolum
- Astesen
- Emdar
- Esmacen
- Fustermizol
- Hestazol
- Histamen
- Histaminos
- Histazol
- Hubermizol
- Kelp
- Laridal
- Metodih
- Metodik
- Paralergin
- Retolen
- Rifedot
- Rimbol
- Romadin
- Simprox
- Urdrim
- Wareezol
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