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PIZOTYLINE
SynDRA canonical compound SYN0002218 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | HTR2C |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | migraine headache |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- HTR1A
- HTR2A
- HTR2C
- CHRM1
- DRD2
- HTR2B
- HTR7
Mechanisms of action (all sources)
- Serotonin receptor antagonist
- HTR1A ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- DRD3
- HRH1
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- SLC6A4
- ADRB2
- KCNH2
- SLC6A2
- CNR1
- DRD1
- HTR3A
- CHRM2
- MC3R
- KDM4A
- MAPT
- MAPK1
- MAOA
- LMNA
- MLNR
- MC4R
- ADORA1
- NPY1R
- NR3C1
- OPRD1
- OPRM1
- PDE3A
- PDE4D
- PTGS2
- SAMHD1
- SLC29A1
- SLC6A3
- TBXA2R
- IDH1
- GLP1R
- HRH3
- HRH2
- ADORA3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- GLI3
- SYK
- RARA
- NSD2
- MDM4
- MDM2
- M4K2
- KSYK
- JUN
- IDHC
- CP3A7
- 5HT2A
- CP3A4
- CP2D6
- CP2CJ
- ANDR
- ADRA1D
- ADRA1B
- ACM5
- ACM4
- ACM1
- TRFR
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Antidepressive Agents
- Central Nervous System Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Psychotropic Drugs
- Sensory System Agents
- Serotonin Agents
- Serotonin Antagonists
ATC classes
- N02C · ANTIMIGRAINE PREPARATIONS
Cross-references
Synonyms
- pizotifen
- pizotifen malate
- Pizotifen
- Pizotifene
- Pizotifeno
- BC-105
- Sandomigran
- Litec
- Sandomygran
- Pizotifenum
- Polomigran
- BC 105
- Pizotyline [USAN]
- Pizotifan
- Pizotifene [INN-French]
- Pizotifenum [INN-Latin]
- Pizotifeno [INN-Spanish]
- UNII-0BY8440V3N
- EINECS 239-632-9
- BRN 0753534
- C19H21NS
- CHEBI:50212
- FIADGNVRKBPQEU-UHFFFAOYSA-N
- Pizotifen (INN)
- Pizotifen [INN]
- 0BY8440V3N
- Pizotyline (USAN)
- 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine
- DTXCID803490
- BC105
- RefChem:174641
- N02CX01
- MFCD00864192
- NCGC00163169-01
- Sandomigran (TN)
- Sandomigram
- CAS-15574-96-6
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