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POMALIDOMIDE
SynDRA canonical compound SYN0002173 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TNF |
|---|
| Mechanism of action | Tumor necrosis factor production inhibitor |
|---|
| Indication | multiple myeloma |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- CRBN
- CUL4A
- DDB1
- RBX1
- TNF
- CYP2C19
Mechanisms of action (all sources)
- angiogenesis inhibitor
- Tumor necrosis factor production inhibitor
- CRBN INHIBITOR
- CRL4(CRBN) E3 ubiquitin ligase inhibitor
- DDB1 INHIBITOR
- CUL4A INHIBITOR
- RBX1 INHIBITOR
- CRBN BINDER
- CRBN MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ZFP91
- IKZF1
- IKZF3
- IL1B
- HSP90AA1
- HTR2B
- IKZF2
- KCNH2
- KDR
- MAOA
- OPRM1
- PDE3A
- PDE4A
- PGR
- PTGS1
- SALL4
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- XIAP
- HTR1A
- ACHE
- ADORA3
- HPGDS
- ADRA1A
- ADRA2A
- ALB
- AR
- BIRC2
- BIRC3
- BTK
- CHRM1
- CHRM2
- CISD1
- DRD1
- DRD3
- ESR1
- F2
- GRAMD1A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CCL3
- CSF2
- IL6
- MDC1
- TP53RK
Drug classes
- Angiogenesis Inhibitors
- Antineoplastic Agents
- Growth Inhibitors
- Growth Substances
- Immunologic Factors
- Thalidomide Analog
ATC classes
- L04A · IMMUNOSUPPRESSANTS
Cross-references
Synonyms
- POMALYST
- Pomalyst
- pomalyst
- actimid
- Pomalidomida
- Actimid
- CC-4047
- IMID-3
- IMID3
- Imnovid
- Imnovid (previously pomalidomide celgene)
- Pomalidomide accord
- Pomalidomide krka
- Pomalidomide viatris
- Pomalidomide zentiva
- Actimid (TN)
- Pomalidomide (Immunomodulator)
- CC 4047
- 4-Aminothalidomide
- (S)-pomalidomide
- D2UX06XLB5
- CHEBI:72690
- MFCD12756407
- Pomalidomide (CC-4047)
- Pomalidomide [USAN:INN]
- UNII-D2UX06XLB5
- HSDB 8222
- Pomalyst (TN)
- CC4047
- Pomalidomide- Bio-X
- IMiD1
- POMALIDOMIDE [MI]
- POMALIDOMIDE [INN]
- POMALIDOMIDE [JAN]
- POMALIDOMIDE [USAN]
- 3-Aminophthalimidoglutarimide
- POMALIDOMIDE [VANDF]
Reported adverse events
- DVT
- Back pain
- Bone pain
- Cough
- Dizziness
- Febrile neutropenia
- Infection
- Nausea
- Neutropenia
- Pneumonia
- Pyrexia
- Thrombocytopenia
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