N-DESMETHYLCLOZAPINE

SynDRA canonical compound SYN0002168 — structure-anchored drug synonym record

Clinical phase	Phase 2
Primary target(s)	HTR2C
Mechanism of action	Acetylcholine receptor agonist

All known targets

CHRM1
DRD2
DRD3
HTR2A
HTR2C

Mechanisms of action (all sources)

Acetylcholine receptor agonist

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

KCNH2
CHRM2
CHRM3
CHRM4
CHRM5
DRD1
HRH1
HTR6
ALOX15B
USP1
UGT1A8
UGT1A4
UGT1A3
TDP1
RGS4
MTOR
GBA1
HDAC6
ATXN2
CYP3A4
CYP2D6
CYP2C9
CYP2C19
CYP1A2
VDR

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

ACM1
CP1A2
CP2C9
CP2D6
CP3A4
CP3A7
KSYK
MAPT
NPR2
SYK

Drug classes

Antipsychotic Agents

Cross-references

PubChem CID: 135409468
ChEMBL: CHEMBL845
DrugBank: DB05766
ChEBI: 64050
Wikipedia: Desmethylclozapine
LINCS BRD: BRD-K10042277

Synonyms

N-Demethylclozapine
desmethylclozapine
Norclozapine
Desmethylclozapine
NDMC
8-Chloro-11-(1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
8-chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
1I9001LWY8
8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,E][1,4]diazepine
CHEBI:64050
8-chloro-11-piperazin-1-yl-5H-dibenzo(B,E)(1,4)diazepine
8-Chloro-11-piperazin-1-yl-5H-dibenzo[b,e][1,4]diazepine
3-chloro-6-piperazin-1-yl-5H-benzo(c)(1,5)benzodiazepine
3-chloro-6-piperazin-1-yl-5H-benzo[c][1,5]benzodiazepine
8-chloro-11-(piperazin-1-yl)-5H-dibenzo(b,e)(1,4)diazepine
RefChem:829786
DTXCID8022616
N-desmethyl-clozapine
Demethylclozapine
Clozapine EP Impurity C
N-DEMETHYLCLOZAPINE
MFCD00210189
3-chloro-6-piperazin-1-yl-11H-benzo[b][1,4]benzodiazepine
Normethylclozapine
Norclozapine;Desmethylclozapine;Normethylclozapine
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(1-piperazinyl)-
C17H17ClN4
UNII-1I9001LWY8
5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(1-piperazinyl)-
Clozapine-M nor
ACP-104
N-Desmethylclozapine?
Tocris-1007
GTPL333
SCHEMBL678149
SCHEMBL781423
orb1302043
SCHEMBL29360816

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