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BRIMONIDINE
SynDRA canonical compound SYN0002166 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRA2C |
|---|
| Mechanism of action | Adrenergic receptor agonist |
|---|
| Indication | glaucoma | intraocular pressure | ocular hypertension |
|---|
| Disease area | ophthalmology |
|---|
All known targets
- ADRA2C
- ADRA2B
- ADRA2A
- ADRA1A
- ADRA1B
- ADRA1D
- AOX1
- Adra1a
- Adra1b
- Adra1d
- Adra2a
- Adra2b
Mechanisms of action (all sources)
- Adrenergic receptor agonist
- ADRA2A AGONIST
- Adrenergic receptor alpha-2 agonist
- ADRA2C AGONIST
- ADRA2B AGONIST
- TADA2A AGONIST
- ADRA2A FULL AGONIST
- ADRA2B PARTIAL AGONIST
- ADRA2C MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- TMEM97
- HTR7
- ACHE
- MMP1
- MBD4
- MBNL1
- MC3R
- MC4R
- MC5R
- MLNR
- MMP9
- MAPK3
- MPG
- MPI
- MUTYH
- NEIL1
- NEIL2
- NPY1R
- MAPT
- MAPK1
- MAPK14
- HTR2C
- HRH4
- HSD17B10
- HTR1B
- HTR1D
- HTR2A
- HTR2B
- HTR3A
- NR1I2
- HTR6
- KCNH2
- KDM4E
- LCK
- LMNA
- MAOA
- NPY2R
- NR3C1
- ADGRF1
- SMUG1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADCY9
- CP2D6
- CP3A7
- DLD
- MCL1
- NTM1A
- PHGDH
Drug classes
- Adrenergic alpha-Agonists
- alpha-Adrenergic Agonist
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-2 Receptor Agonists
- Antihypertensive Agents
- Cardiovascular Agents
- Neurotransmitter Agents
ATC classes
- S01G · DECONGESTANTS AND ANTIALLERGICS
- S01E · ANTIGLAUCOMA PREPARATIONS AND MIOTICS
- D11A · OTHER DERMATOLOGICAL PREPARATIONS
Cross-references
Synonyms
- ALPHAGAN
- ALPHAGAN P
- Alphagan
- BRIMONIDINE TARTRATE
- BRIMONIDINE TARTRATE AND TIMOLOL MALEATE
- COMBIGAN
- LUMIFY
- LUMIFY PRESERVATIVE FREE
- Lumify
- MIRVASO
- Mirvaso
- QOLIANA
- UK 14,304
- mirvaso
- brimonidine tartrate
- bromoxidine
- Brimonidina
- AGN-190342 FREE BASE
- NSC-318825
- UK-14304
- UK-1430418 FREE BASE
- Brominide tartrate
- Brimonidine tartarate
- Brimonidine D-tartrate
- UNII-4S9CL2DY2H
- Brimonidinne tartrate
- C11H10BrN5.C4H6O6
- Brimonidine L-Tartrate
- Brimonidine (tartrate)
- Brimonidine D-tartarate
- 4S9CL2DY2H
- UK-14304-18
- Qoliana
- brimonidine Purite
- Brimonidine tartrate [USAN]
- Bromoxidine
- UK 14304
- AGN-190342
Reported adverse events
- Hypersensitivity
- Agranulocytosis
- Alopecia
- Arrhythmia
- Arthralgia
- Bronchial obstruction
- Bronchospasm
- Gastrointestinal pain
- Systemic lupus erythematosus
- Vasodilatation
- Bradycardia
- Raynaud's phenomenon
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