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CHLOROTHIAZIDE

SynDRA canonical compound SYN0002159 — structure-anchored drug synonym record

All known targets

• SLC12A3
• CA2
• CA1
• CA4

Mechanisms of action (all sources)

• SLC12A3 INHIBITOR
• Thiazide-sensitive sodium-chloride cotransporter inhibitor
• CA2 INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ADORA1
• HDAC6
• NPY1R
• NFKB1
• MLNR
• MC4R
• MC3R
• MAOA
• LMNA
• KCNH2
• HTR3A
• HTR2C
• HTR2B
• HTR2A
• HTR1A
• HRH3
• HRH2
• NR3C1
• OPRD1
• OPRK1
• SLC6A2
• TSHR
• TBXA2R
• SLCO1B3
• SLCO1B1
• SLC6A4
• SLC6A3
• SLC29A1
• OPRM1
• SAMHD1
• RGS4
• PTGS2
• PGR
• PDE4D
• PDE3A
• HRH1
• GMNN
• ADORA2A
• GHSR
• BLM

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ESR2

Drug classes

• Thiazide Diuretic
• Antihypertensive Agents
• Cardiovascular Agents
• Diuretics
• Membrane Transport Modulators
• Natriuretic Agents
• Sodium Chloride Symporter Inhibitors
• Diuretic

ATC classes

• C03A · LOW-CEILING DIURETICS, THIAZIDES

Cross-references

• PubChem CID: 2720
• ChEMBL: CHEMBL842
• DrugBank: DB00880
• ChEBI: CHEBI:3640
• KEGG: D00519
• RxNorm: 2396
• Wikipedia: Chlorothiazide
• TTD: D0M9WM
• LINCS BRD: BRD-K88682005

Synonyms

• ALDOCLOR-150
• ALDOCLOR-250
• CHLOROTHIAZIDE AND RESERPINE
• CHLOROTHIAZIDE SODIUM
• CHLOROTHIAZIDE W/ RESERPINE
• CHLOROTHIAZIDE-RESERPINE
• DIUPRES-250
• DIUPRES-500
• DIURIL
• Diuril
• METHYLDOPA AND CHLOROTHIAZIDE
• chlorothiazide sodium
• Clorotiazida
• NSC-25693
• Saluric
• Hydrochlorothiazide impurity, chlorothiazide-
• Aldoclor
• Alurene
• Chloriazid
• Chlorosal
• Chlorothiazid
• Chlorothiazidum
• Chlorotiazida
• Chlorthiazid
• Chlorthiazide
• Chlorthiazidum
• Chlortiazid
• Chlorurit
• Chlotride
• Chlrosal
• Clorotiazide
• Clotride
• Diupres
• Diuresal
• Diurilix
• Diurite
• Diutrid

Reported adverse events

• Erythema multiforme
• Hypersensitivity
• Hypotension
• Stevens-Johnson syndrome
• Anaphylactic reaction
• Electrolyte imbalance
• Pancreatitis
• Renal failure
• Vertigo