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LOPERAMIDE
SynDRA canonical compound SYN0002153 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | OPRM1 |
|---|
| Mechanism of action | Opioid receptor agonist |
|---|
| Indication | diarrhea |
|---|
| Disease area | gastroenterology |
|---|
All known targets
- OPRM1
- OPRD1
- CACNA1A
- OPRK1
- CALM1
- ADRA1D
- Pgrmc1
- MEN1
- NPR2
- Oprd1
- Oprm1
- POMC
Mechanisms of action (all sources)
- Opioid receptor agonist
- OPRM1 AGONIST
- Mu opioid receptor agonist
- OPRD1 BINDER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB1
- GPR183
- MTOR
- DRD1
- C5AR2
- C5AR1
- C3AR1
- FFAR4
- FPR1
- FPR2
- GLP1R
- GPR119
- SLC6A3
- GPR35
- ADRA2A
- HTR1D
- KCNH2
- HTR1A
- ADGRF1
- TMEM97
- NPY2R
- HTT
- MMP1
- NPY1R
- NPSR1
- NFE2L2
- NEIL2
- NEIL1
- KDR
- MPHOSPH8
- HTR6
- MMP9
- MC5R
- NR3C1
- LMNA
- MC3R
- MAPK3
- IDH1
- LCK
- HTR7
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- BARD1
- KCMB4
- KSYK
- M4K2
- MDM2
- MDM4
- MDR1
- MLP3A
- NNMT
- NSD2
- OPRD
- PDE4B
- PNMT
- SMAD2
- SMAD3
- STK33
- KCMB2
- KCMB1
- KCMA1
- CP3A4
- BRCA1
- CAC1H
- CFTR
- COMT
- CP19A
- CP2D6
- CP3A7
- IL1B
- ESRRA
- GAMT
- GNMT
- HNMT
- HXA9
- IDHC
- SYK
Drug classes
- Opioid Agonists
- Antidiarrheals
- Gastrointestinal Agents
- Opioid Agonist
ATC classes
Cross-references
Synonyms
- Diamode
- IMODIUM
- IMODIUM A-D
- IMODIUM A-D EZ CHEWS
- IMODIUM MULTI-SYMPTOM RELIEF
- Imodium
- Imodium Advanced
- Imodium Multi-Symptom Relief
- LOPERAMIDE HYDROCHLORIDE
- LOPERAMIDE HYDROCHLORIDE AND SIMETHICONE
- loperamide hydrochloride
- imodium
- loperamide HCl
- Loperamida
- Ioperamide
- Loperacap
- Loperamidum
- Kaopectate II
- Loperamide Monohydrochloride
- Pepto Diarrhea Control
- Apo-Loperamide
- Diamide (TN)
- Diarr-Eze
- Dimor (TN)
- Imodium (TN)
- Imodium A-D Caplets
- Loperamida [INN-Spanish]
- Loperamide (INN)
- Loperamide [INN:BAN]
- Loperamidum [INN-Latin]
- Lopex (TN)
- Maalox Anti-Diarrheal
- Nu-Loperamide
- PMS-Loperamide
- Pepto (TN)
- R-18553
- Rho-Loperamide
- loperamide oxide monohydrate impurity a (ep impurity)
Reported adverse events
- Rash
- Constipation
- Urinary retention
- Dizziness
- Dry mouth
- Nausea
- Stevens-Johnson syndrome
- Gastrointestinal disorder
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