RHEIN

SynDRA canonical compound SYN0002139 — structure-anchored drug synonym record

Clinical phase	Phase 1
Primary target(s)	HSP90AA1

All known targets

HSP90AA1

Mechanisms of action (all sources)

HSP90AA1 INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

B2CL1
CASP6
SYK
SIX1
RBBP9
RBBP8
PTN7
PRMT1
PIP4K2A
PAFA2
PAFA
NF2L2
MCL1
LOX15
KSYK
HS90B
HS90A
HKDC1
HDAC9
GSTO1
GLSK
DPOLB
DNMT1
CXCR6
CTDS1
CP1A2
CIB1
CDK2
CCR6
TP53

Drug classes

Enzyme Inhibitors

Cross-references

PubChem CID: 10168
ChEMBL: CHEMBL418068
DrugBank: DB13174
ChEBI: 8825
KEGG: C10401
PDB: RHN
Wikipedia: Rhein (molecule)
TTD: D0M2TY
LINCS BRD: BRD-K27335680

Synonyms

Monorhein
Rheic acid
Rhubarb Yellow
Cassic acid
4,5-Dihydroxyanthraquinone-2-carboxylic acid
Chrysazin-3-carboxylic acid
4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
NSC 38629
Rheinic acid
1,8-Dihydroxyanthraquinone-3-carboxylic acid
dipropionyl rhein
1,8-Dihydroxy-3-carboxyanthraquinone
UNII-YM64C2P6UX
Rhein(Monorhein)
2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-
CCRIS 5129
9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
C15H8O6
4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
YM64C2P6UX
2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-
DTXCID606000
1,8-dihydroxy-3-carboxyl-9,10-anthraquinone
RefChem:882948
MFCD00009618
Rhein (Standard)
4,5-Dihydroxy-2-anthraquinonecarboxylic acid
MLS000069639
4,5-DiOH-anthraquinone-2-COOH
Rhein (1,8-dihydroxy-3-carboxyl anthraquinone)
4,5-dihydroxy-9,10-dioxo-anthracene-2-carboxylic acid
SMR000058210
ST057726
Chrysazin-3-carboxylicacid
9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroic acid
Parietic acid
Diacerein EP Impurity C

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