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7-ETHYL-10-HYDROXYCAMPTOTHECIN
SynDRA canonical compound SYN0002131 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | TOP1 |
|---|
| Mechanism of action | Topoisomerase inhibitor |
|---|
| Indication | colorectal cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- TOP1
- CYP3A5
- TOP1MT
- ABCB1
- CHRM4
- ABCC2
- ADRA2C
- ABCC1
- ABCG2
- ABCC4
- ACHE
- MMP1
Mechanisms of action (all sources)
- topoisomerase inhibitor
- TOP1 INHIBITOR
- DNA topoisomerase I inhibitor
- TOP1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCC1
- ABCG2
- UGT1A9
- UGT1A7
- UGT1A6
- UGT1A4
- UGT1A1
- SLCO2B1
- SLCO1B3
- SLCO1B1
- HDAC8
- HDAC6
- HDAC1
- CYP3A4
- BRD4
- ALB
- ACHE
- UGT2B15
Drug classes
- Topoisomerase Inhibitors
- Antineoplastic Agents
- Enzyme Inhibitors
- Topoisomerase I Inhibitors
- Topoisomerase Inhibitor
ATC classes
- L01C · PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Cross-references
Synonyms
- 7-ethyl-10-hydroxy-camptothecin
- Camptothecin, 7-ethyl-10-hydroxy-
- IT-141
- NK012
- NK-012
- SN-38
- SN38
- Irinotecan related compound b
- LE-SN38
- SN 38
- SN 38 lactone
- 7-Ethyl-10-hydroxy camptothecin
- 10-Hydroxy-7-ethylcamptothecin
- 7-Ethyl-10-hydroxycamptothecine
- 7-Ethyl-10-hydroxy-20(S)-camptothecin
- UNII-0H43101T0J
- Captothecin, 7-ethyl-10-hydroxy-
- CHEBI:8988
- (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- NSC673596
- 0H43101T0J
- (+)-7-ETHYL-10-HYDROXYCAMPTOTHECIN
- NK 012
- CAMPTOTHECIN, 7-ETHYL-10-HYDROXY-
- RefChem:914300
- DTXCID2020399
- 7-Ethyl-10-hydroxy-camptothecin
- MFCD00871873
- C22H20N2O5
- 7-10-hydroxycamptothecin
- AvaChem1025
- SN-38 (Standard)
- diethyl(dihydroxy)[?]dione
- SCHEMBL34018
- GTPL6925
- orb1307686
- orb3141304
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