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EDARAVONE

SynDRA canonical compound SYN0002112 — structure-anchored drug synonym record

All known targets

• BCL2
• Alox15

Mechanisms of action (all sources)

• BCL2 REGULATOR (UPREGULATOR)

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• UGT1A9
• ACHE
• NT5E
• MT-CO1
• MT-CO2
• NFE2L2
• NPY1R
• NPY2R
• NR3C1
• OPRD1
• MMP1
• OPRK1
• OPRM1
• PDE3A
• PDE4A
• PDE5A
• MMP9
• MC5R
• POLI
• MC4R
• MC3R
• MAPT
• MAPK3
• MAPK14
• MAPK1
• MAOB
• MAOA
• LCK
• KMT2A
• KDR
• KDM4E
• KCNH2
• IDH1
• PGR
• PPARG
• HTR2C
• PPP3CA
• VDR
• UGT2B7
• UGT2B4

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ACES
• ADCY9
• TYDP2
• TLR3
• TERA
• SYK
• SENP8
• SAE1
• ROCK2
• PSIP1
• PLCG1
• PADI4
• MBD2
• KSYK
• IP6K1
• GSTO1
• ESRRA
• CP3A7
• CP3A4
• CP2D6
• CP2CJ
• CP2C9
• CP1A2
• APAF
• AHR
• UBA2

Drug classes

• Antioxidants
• Central Nervous System Agents
• Free Radical Scavengers
• Neuroprotective Agents
• Protective Agents
• nootropic agent

ATC classes

• N07X · OTHER NERVOUS SYSTEM DRUGS

Cross-references

• PubChem CID: 4021
• ChEMBL: CHEMBL290916
• DrugBank: DB12243
• ChEBI: CHEBI:31530
• KEGG: D01552
• RxNorm: 1921877
• PDB: W1P
• Wikipedia: Edaravone
• TTD: D06DLI
• LINCS BRD: BRD-K35458079

Synonyms

• RADICAVA
• RADICAVA ORS
• Radicava
• radicava
• edarabone
• methylphenylpyrazolone
• norantipyrine
• norphenazone
• radicut
• Edaravona
• Norphenazone
• C.i. developer 1
• Colorex pmp
• Developer z
• Jarocol pmp
• Phenyl methyl pyrazolone
• MCI-186
• NSC-12
• NSC-26139
• NSC-2629
• Radicava ors
• Radicut
• Antipyrine related compound a
• MCI 186
• Edarabone
• Methylphenylpyrazolone
• Monopyrazolone
• Norantipyrine
• Phenylmethylpyrazolone
• Developer Z
• Edaravone [INN]
• CDS1_000986
• CI Developer 1
• IN1263
• M0687
• Edaravone(jan)
• Radicut (TN)

Reported adverse events

• Dermatitis
• Eczema
• Gait disturbance
• Glycosuria
• Headache
• Hypersensitivity
• Respiratory failure
• Contusion
• Tinea infection