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LOXAPINE
SynDRA canonical compound SYN0002093 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR6 |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- DRD4
- DRD3
- HTR2C
- HTR2A
- HTR6
- HRH1
- DRD1
- ADRA1A
- HTR1A
- HRH4
- HTR1E
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- Serotonin receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR2C ANTAGONIST
- Serotonin 2c (5-HT2c) receptor antagonist
- DRD2 ANTAGONIST
- D2-like dopamine receptor antagonist
- DRD3 ANTAGONIST
- DRD4 ANTAGONIST
- HTR2A INVERSE AGONIST
- HTR2C INVERSE AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR2B
- ADRB2
- OPRK1
- OPRD1
- OPRM1
- KCNH2
- KDR
- LMNA
- MAOA
- MC3R
- MC4R
- PDE3A
- MPHOSPH8
- NFE2L2
- NPY1R
- NPY2R
- NR3C1
- NTSR1
- IDH1
- MLNR
- ABCB11
- HRH3
- SLCO1B3
- UGT1A4
- UGT1A3
- TDP1
- TBXA2R
- TACR2
- TACR1
- SMN1
- SLCO1B1
- PDE4D
- SLC29A1
- SAMHD1
- PTGS2
- PTGS1
- PMP22
- PGR
- PDE6A
- PDE4A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT6R
- ESRRA
- NR1I2
- NPR2
- NCF1
- MDR1
- JUN
- GLI3
- CP3A7
- ACM4
- CP3A4
- CP2D6
- CP2CJ
- CP1A2
- ANDR
- ACM5
- PRGR
Drug classes
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Neurotransmitter Agents
- Psychotropic Drugs
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- ADASUVE
- Adasuve
- LOXAPINE SUCCINATE
- LOXITANE
- LOXITANE C
- LOXITANE IM
- loxapin
- oxilapine
- loxapine succinate
- cloxazepine
- loxitane
- adasuve
- loxapine hydrochloride
- loxapine HCl
- loxipine maleate
- Loxapina
- CL 62,362
- CL-62362
- SUM-3170
- Cloxazepine
- Dibenzacepin
- Dibenzoazepine
- Lossapina
- Loxapin
- Loxapinsuccinate
- Loxapinum
- Loxepine
- Oxilapine
- Lossapina [DCIT]
- Loxitane IM
- HF 3170
- HF3170
- Hydrofluoride 3170
- LW 3170
- S 805
- SUM 3170
- Loxapac (TN)
- Loxapina [INN-Spanish]
Reported adverse events
- Neuroleptic malignant syndrome
- Akathisia
- Dermatitis
- Dizziness
- Dry mouth
- Dyskinesia
- Dystonia
- Hepatocellular injury
- Nausea
- Tachycardia
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