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EFLORNITHINE
SynDRA canonical compound SYN0002086 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | ODC1 |
|---|
| Mechanism of action | Ornithine decarboxylase inhibitor |
|---|
| Indication | facial hair reduction |
|---|
| Disease area | dermatology |
|---|
All known targets
Mechanisms of action (all sources)
- Ornithine decarboxylase inhibitor
- ODC1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA1
- ADORA2A
- HRH2
- HRH3
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MLNR
- NFE2L2
- NPY1R
- NR1I2
- NR3C1
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PTGS2
- RGS4
- SLC22A1
- SLC6A2
- SLC6A3
- SLC6A4
- HRH1
- HMBS
- GHSR
- CCKAR
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antiprotozoal
- Anti-Infective Agents
- Antineoplastic Agents
- Antiparasitic Agents
- Antiprotozoal Agents
- Enzyme Inhibitors
- Ornithine Decarboxylase Inhibitors
- Trypanocidal Agents
- Decarboxylase Inhibitors
- Decarboxylase Inhibitor
ATC classes
- D11A · OTHER DERMATOLOGICAL PREPARATIONS
- L01X · OTHER ANTINEOPLASTIC AGENTS
- P01C · AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS
Cross-references
Synonyms
- IWILFIN
- Iwilfin
- ORNIDYL
- VANIQA
- eflornithine hydrochloride monohydrate
- eflornithine hydrochloride anhydrous
- vaniqa
- eflornithine hydrochloride
- elfornithine
- ornidyl
- alpha-(Difluoromethyl)-DL-ornithine
- eflornithine hydrochloride hydrate
- eflornithine HCl
- Eflornitina
- Ornidyl
- 2-(Difluoromethyl)ornithine
- alpha-Difluoromethylornithine
- Difluromethylornithine
- Eflornitina [Spanish]
- Eflornithinum [Latin]
- 2,5-diamino-2-(difluoromethyl)pentanoic acid
- N-Difluoromethylornithine
- DFMO (growth regulator)
- Eflornithine [INN:BAN]
- 2-(Difluoromethyl)-DL-ornithine
- DL-alpha-(Difluoromethyl)ornithine
- MDL 71782
- CCRIS 3295
- Ornithine, 2-(difluoromethyl)-
- Eflornithinum
- DFMO hydrochloride
- DFMO hydrochloride hydrate
- EFLORNITHINE HYDROCHLORIDE
- BMS 203522
- Alpha-DFMO HCl
- Alpha-Difluoromethylornithine hydrochloride
- CPP-1X
- Eflornithine (INN)
Reported adverse events
- Pseudofolliculitis
- Acne
- Alopecia
- Asthenia
- Dizziness
- Dyspepsia
- Erythema
- Folliculitis
- Headache
- Nausea
- Pruritus
- Rash
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