← SynDRA

PIPERINE

SynDRA canonical compound SYN0002080 — structure-anchored drug synonym record

All known targets

• MAOA
• MAOB
• TRPV1

Mechanisms of action (all sources)

• monoamine oxidase inhibitor
• MAOA INHIBITOR
• MAOB INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• DHODH
• HDAC6
• ABCB1
• NFE2L2
• SMPD1
• SMN1
• SLCO1B3
• SAMHD1
• RXRA
• RAB9A
• PPARG
• POLI
• NR3C1
• NR1H4
• NPC1
• KDM4E
• MAPK1
• AHR
• HSD17B10
• HPGD
• CYP3A4
• CYP1A1
• CTSD
• BRCA1
• ATXN2
• ATAD5
• ALOX5
• ALDH1A1
• TDP1

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• 5HT2A
• CP1A2
• RARA
• PRGR
• PHGDH
• NR1I3
• NR1I2
• NR0B1
• NF2L2
• MDR1
• HDAC9
• GLI3
• GABRG2
• GABRB2
• GABRA1
• ESRRA
• ESR2
• ESR1
• CP3A7
• CP3A4
• CP2D6
• CP2CJ
• CP2C9
• SMN

Drug classes

• Cytochrome P-450 Enzyme Inhibitors

Cross-references

• PubChem CID: 638024
• ChEMBL: CHEMBL43185
• DrugBank: DB12582
• ChEBI: 28821
• KEGG: C03882
• RxNorm: 1311146
• PDB: AYR
• Wikipedia: Piperine
• TTD: D0H7PW

Synonyms

• Bioperine
• FEMA NO. 2909
• NSC-21727
• 1-Piperoylpiperidine
• Piperin
• Piperoylpiperidine
• (E,E)-1-piperoylpiperidine
• N-[(E,E)-Piperoyl]piperidine
• Piperidine, 1-piperoyl-, (E,E)-
• UNII-U71XL721QK
• FEMA No. 2909
• CCRIS 5572
• Piperine (aliphatic)
• 1-Piperoylpiperidine, (E,E)-
• C17H19NO3
• EINECS 202-348-0
• NSC 21727
• 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]piperidine
• N-(E,E)-piperoyl-piperidine
• CHEMBL43185
• U71XL721QK
• CHEBI:28821
• MXXWOMGUGJBKIW-YPCIICBESA-N
• NSC21727
• piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)
• (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one
• AI 3-01439
• piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-
• (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one
• (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
• Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)-
• Piperidine, 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (E,E)-
• Piperidine, 1-(5-(3,4-methylenedioxyphenyl)-1-oxo-2,4-pentadienyl)-
• 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine
• 1-[(2E,4E)-5-(1,3-Benzodioxol-5-yl)-2,4-pentadienoyl]piperidine
• 5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one
• Piperidine, 1-((2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-