← SynDRA

BREQUINAR

SynDRA canonical compound SYN0002055 — structure-anchored drug synonym record

All known targets

• DHODH

Mechanisms of action (all sources)

• Dihydroorotate dehydrogenase inhibitor
• DHODH INHIBITOR
• DHODH MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ALKBH5
• DHFR
• HDAC6

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• KSYK
• NSD2
• PARP1
• SYK

Drug classes

• Antineoplastic Agents
• Enzyme Inhibitors
• Immunosuppressive Agents

Cross-references

• PubChem CID: 57030
• ChEMBL: CHEMBL38434
• DrugBank: DB03523
• ChEBI: 177387
• KEGG: D03154
• PDB: BRF
• Wikipedia: Brequinar
• TTD: D0N3XT
• LINCS BRD: BRD-K96123349

Synonyms

• 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
• brequinarum [Latin]
• Brequinar [INN]
• Biphenquinate
• 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
• Brequinarum [INN-Latin]
• UNII-5XL19F49H6
• C23H15F2NO2
• NSC 368390
• 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
• PHEZJEYUWHETKO-UHFFFAOYSA-N
• Dup 785
• 5XL19F49H6
• 6-FLUORO-2-(2'-FLUORO-1,1'-BIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID
• brequinarum
• DUP785
• Bipenquinate
• NSC368390
• 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-quinoline-4-carboxylic acid
• 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methyl-
• 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-
• 6-fluoro-2-{2'-fluoro-[1,1'-biphenyl]-4-yl}-3-methylquinoline-4-carboxylic acid
• BREQUINAR [MI]
• BREQUINAR [WHO-DD]
• Neuro_000208
• SCHEMBL49400
• CHEMBL38434
• DUP785; Biphenquinate; BPQ
• GTPL7406
• BDBM15339
• DTXSID00242165
• TQR0591
• CHEBI:177387
• HMS3749M07
• AMY36630
• BCP06006
• EX-A1515