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TERBINAFINE
SynDRA canonical compound SYN0002043 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP2C19 | CYP2C8 | SQLE |
|---|
| Mechanism of action | fungal squalene epoxidase inhibitor |
|---|
| Indication | tinea corporis | tinea cruris | tinea pedis |
|---|
| Disease area | infectious disease |
|---|
All known targets
- SQLE
- ADRA2A
- CYP2C19
- CYP2C8
- CYP2D6
- Candi ERG1
- Pgrmc1
- SIGMAR1
- SLC6A2
- Sqle
Mechanisms of action (all sources)
- fungal squalene epoxidase inhibitor
- Candi ERG1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KCNH2
- FLT1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KCNK9
- ACHE
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HRH2
- HRH1
- HMGCR
- HDAC6
- GMNN
- GLP1R
- MMP1
- MMP9
- NPY1R
- PTGS2
- USP1
- TDP1
- TBXAS1
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- RAPGEF4
- PTPRC
- PTGS1
- NPY2R
- PTAFR
- PRKCA
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- CFTR
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- GPR32
- KCMB1
- KCMB2
- NR1I2
Drug classes
- Anti-Infective Agents
- Antifungal Agents
- Enzyme Inhibitors
- Allylamine Antifungal
ATC classes
- D01A · ANTIFUNGALS FOR TOPICAL USE
- D01B · ANTIFUNGALS FOR SYSTEMIC USE
Cross-references
Synonyms
- Dermasil
- LAMISIL
- LAMISIL AT
- Lamisil
- TERBINAFINE HYDROCHLORIDE
- terbinol
- terbinafine hydrochloride
- terbinafine HCl
- Terbinafina
- SF-86-327
- TDT-067
- Lamasil
- Lamisil at
- Terbinafine component of osurnia
- Bramazil
- TerbiFoam
- Terbina
- Lamisil AT
- Lamisil Tablet
- Ternbinafine HCl
- Lamasil (TN)
- Lamisil (TN)
- Terbisil (TN)
- Zabel (TN)
- Terbinafine (USAN/INN)
- Terbinafine [USAN:BAN:INN]
- Lamisil, Terbinex, Corbinal, Zabel, Terbinafine
- Terbinafine, SF-86-327, Lamisil, TBNF
- G7RIW8S0XP
- terbinafine (ema epar veterinary)
- OSURNIA COMPONENT TERBINAFINE
- SF 86-327
- TDT 067
- Terbinafinum
- CHEBI:9448
- DTXCID703640
- RefChem:56103
- TDT067
Reported adverse events
- Stevens-Johnson syndrome
- Depressive symptom
- Anxiety
- Malaise
- Pancreatitis
- Pancytopenia
- Rash
- Rhabdomyolysis
- Vasculitis
- Visual field defect
- Dyspepsia
- Flatulence
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