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TOLAZAMIDE
SynDRA canonical compound SYN0002025 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | ABCC8 | KCNJ1 | KCNJ10 | KCNJ11 |
|---|
| Mechanism of action | ATP channel blocker |
|---|
| Indication | diabetes mellitus |
|---|
| Disease area | endocrinology |
|---|
All known targets
- ABCC8
- KCNJ11
- KCNJ10
- ALOX15
- KCNJ1
Mechanisms of action (all sources)
- KCNJ11 BLOCKER
- Sulfonylurea receptor 1, Kir6.2 blocker
- ABCC8 BLOCKER
- ATP channel blocker
- KCNJ10 BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD2
- ESR1
- ACHE
- MAPT
- LCK
- MAOA
- MAPK1
- MAPK14
- MAPK3
- MC3R
- KDM4A
- MC4R
- MC5R
- MLNR
- MMP1
- MMP9
- KDM4E
- KCNH2
- NFKB1
- KAT2A
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- NFE2L2
- NPY1R
- GLS
- NPY2R
- USP1
- TP53
- TBXAS1
- TBXA2R
- TACR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- GLSK
- MLP3A
- MPI
Drug classes
- Sulfonylurea
- Hypoglycemic Agents
ATC classes
- A10B · BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Cross-references
Synonyms
- TOLINASE
- norglycin
- tolanase
- tolinase
- Tolazamida
- NSC-70762
- U-17835
- Tolinase
- Diabewas
- Norglycin
- Tolamide
- Tolanase
- Tolazamidum
- Tolazolamide
- Pharmacia Brand of Tolazamide
- T 2408
- Tolazamida [INN-Spanish]
- Tolazamidum [INN-Latin]
- Tolinase (TN)
- Tolazamide (JP15/USP/INN)
- Tolazamide [USAN:INN:BAN:JAN]
- N-(p-Toluenesulfonyl)-N'-hexamethyleniminourea
- N-[(azepan-1-ylamino)carbonyl]-4-methylbenzenesulfonamide
- 1-(((((4-Methylphenyl)sulfonyl)amino)carbonyl)amino)azepane
- 1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea
- 1-(Hexahydro-1H-azepin-1-yl)-3-(p-toluenesulfonyl)urea
- 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea
- 1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
- 4-(p-Tolylsulfonyl)-1,1-hexamethylene
- 4-(p-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide
- 59866P
- NSC 70762
- U 17835
- NCI-C03327
- CCRIS 591
- N-(azepan-1-ylcarbamoyl)-4-methylbenzenesulfonamide
- BRN 1323565
Reported adverse events
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