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MEMANTINE
SynDRA canonical compound SYN0001957 — structure-anchored drug synonym record
| Clinical phase | Launched |
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| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GRIN1 |
|---|
| Mechanism of action | Glutamate receptor antagonist |
|---|
| Indication | Alzheimer's disease | senile dementia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- GRIN1
- GRIN2A
- GRIN2B
- GRIN3A
- ACHE
- CD4
- CD8A
- CD8B
- CYP2E1
- GRIN2C
- GRIN2D
- GRIN3B
Mechanisms of action (all sources)
- Glutamate receptor antagonist
- GRIN1 NEGATIVE ALLOSTERIC MODULATOR
- GRIN2A NEGATIVE ALLOSTERIC MODULATOR
- GRIN2B NEGATIVE ALLOSTERIC MODULATOR
- GRIN2D NEGATIVE ALLOSTERIC MODULATOR
- GRIN3B NEGATIVE ALLOSTERIC MODULATOR
- GRIN2C NEGATIVE ALLOSTERIC MODULATOR
- GRIN3A NEGATIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- ADORA1
- MAOB
- NPY1R
- NPSR1
- NFE2L2
- MTOR
- MLNR
- MC4R
- MC3R
- MAPT
- MAOA
- HRH2
- LMNA
- KCNH2
- IDH1
- HTT
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- NPY2R
- NR3C1
- NTSR1
- SLC29A1
- TRPV1
- TDP1
- TBXA2R
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC22A2
- OPRD1
- SAMHD1
- PTGS2
- PMP22
- PGR
- PDE4D
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- GLI3
- GRIN2D
- GRIN3B
- KSYK
- RARA
- SYK
- TNNC1
- TNNI3
- TNNT2
Drug classes
- NMDA Receptor Antagonists
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Central Nervous System Agents
- Dopamine Agents
- Excitatory Amino Acid Antagonists
- Neurotransmitter Agents
- N-methyl-D-aspartate Receptor Antagonist
ATC classes
- N06D · ANTI-DEMENTIA DRUGS
Cross-references
Synonyms
- MEMANTINE HYDROCHLORIDE
- MEMANTINE HYDROCHLORIDE AND DONEPEZIL HYDROCHLORIDE
- NAMENDA
- NAMENDA XR
- NAMZARIC
- Namenda
- alzantin
- memantina
- memantine hydrochloride
- ebixa
- namenda
- maruxa
- memantine HCl
- nemdatine
- Memantina
- D-145
- DRG-0267
- NSC-757843
- Memantine ER
- Namenda XR
- Memantine (extended release)
- Memantine (extended release), Forest
- 3,5-Dimethyl-1-adamantanamine
- D 145
- TRICYCLO(3.3.1.1(SUP 3,7))DECAN-1-AMINE, 3,5-DIMETHYL-
- NSC 757843
- W8O17SJF3T
- 3,5-DIMETHYLTRICYCLO(3.3.1.1(SUP 3,7))DECAN-1-AMINE
- 1-Amino-3,5-dimethyladamantane
- DRG 0267
- 3,5-dimethyladamantan-1-amine
- Memantinum
- 1,3-Dimethyl-5-adamantanamine
- 3,5-Dimethyl-1-aminoadamantane
- Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-
- 1,3-Dimethyl-5-aminoadamantane
- DTXCID3025174
- CHEBI:64312
Reported adverse events
- Hallucination
- Somnolence
- Constipation
- Headache
- Vomiting
- Dizziness
- Hypertension
- Seizure
- Fatigue
- Cough
- Back pain
- Parkinsonism
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