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MINOXIDIL
SynDRA canonical compound SYN0001932 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | KCNJ11 |
|---|
| Mechanism of action | Potassium channel activator |
|---|
| Indication | androgenetic alopecia |
|---|
| Disease area | endocrinology |
|---|
All known targets
- KCNJ11
- ABCC9
- KCNJ8
- KCNJ1
- KCNJ10
- MPC1L
- MPC2
- PTGS1
- REN
Mechanisms of action (all sources)
- KATP activator
- Potassium channel activator
- KCNJ11 OPENER
- Sulfonylurea receptor 2, Kir6.2 opener
- ABCC9 OPENER
- KCNJ8 MODULATOR
- KCNJ11 MODULATOR
- MPC1L INHIBITOR
- MPC2 INHIBITOR
- Kir6 channel (KATP) activator
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- LCK
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- KMT2A
- GMNN
- KCNH2
- KAT2A
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- NR1I2
- NR3C1
- OPRD1
- OPRK1
- USP1
- TTR
- TSHR
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Arteriolar Vasodilator
- Antihypertensive Agents
- Cardiovascular Agents
- Vasodilator Agents
- Vasodilator
ATC classes
- C02D · ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
- D11A · OTHER DERMATOLOGICAL PREPARATIONS
Cross-references
Synonyms
- LONITEN
- MEN'S ROGAINE
- MINODYL
- MINOXIDIL (FOR MEN)
- MINOXIDIL (FOR WOMEN)
- MINOXIDIL EXTRA STRENGTH (FOR MEN)
- ROGAINE (FOR MEN)
- ROGAINE (FOR WOMEN)
- ROGAINE EXTRA STRENGTH (FOR MEN)
- Rogaine
- THEROXIDIL
- loniten
- rogaine
- Alopexil
- Alostil
- Minoximen
- Mintop
- Normoxidil
- Pierminox
- Prexidil
- Tricoxidil
- NSC-757106
- U-10,858
- U-10858
- Loniten
- Lonolox
- Men's rogaine
- Minodyl
- Minoxidil (for men)
- Minoxidil (for women)
- Minoxidil extra strength (for men)
- Regaine for men
- Regaine for women
- Riup
- Rogaine (for men)
- Rogaine (for women)
- Rogaine extra strength (for men)
Reported adverse events
- Pericarditis
- Hypertrichosis
- Nausea
- Rash
- Thrombocytopenia
- Breast tenderness
- Stevens-Johnson syndrome
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