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FASUDIL
SynDRA canonical compound SYN0001926 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | ROCK2 |
|---|
| Mechanism of action | Rho associated kinase inhibitor |
|---|
| Indication | cerebral vasospasm |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- ROCK1
- ROCK2
- PRKACA
- BMP2K
- PKN1
- RPS6KA5
- PRKD3
- PRKD2
- PRKCE
- PRKCD
- PKN3
- PKN2
Mechanisms of action (all sources)
- Rho associated kinase inhibitor
- ROCK2 INHIBITOR
- Rho-associated protein kinase inhibitor
- ROCK1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SLC6A4
- PRKX
- ESR1
- PGR
- CHEK2
- SGK2
- AKT1
- STK33
- AKT3
- BRSK2
- RPS6KB1
- RPS6KA3
- AURKB
- MKNK2
- HRH1
- MKNK1
- CLK4
- CYP2D6
- ADRA2A
- RPS6KA1
- DAPK3
- PRKD1
- PRKACB
- PRKACG
- CDK7
- CDK5
- LRRK2
- DYRK3
- PAK1
- NTRK1
- NTRK2
- NTRK3
- NTSR1
- PAK2
- OPRD1
- NUAK1
- OPA1
- PAICS
- OXSR1
- OLA1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- ATXN2
- RARA
- NF2L2
- MDM4
- MDM2
- M4K4
- KS6B1
- KS6A3
- KPCT
- KPCG
- KPCD3
- KPCD2
- KPCD1
- KPCD
- KAPCA
- GPR151
- GLI3
- ESRRA
- CREB1
- CP3A7
- CP3A4
- CP2D6
- CP19A
- CFTR
- BRCA1
- BARD1
- SMAD2
Drug classes
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Enzyme Inhibitors
- Membrane Transport Modulators
- Protein Kinase Inhibitors
- Vasodilator Agents
ATC classes
- C04A · PERIPHERAL VASODILATORS
Cross-references
Synonyms
- fasudil HCl semihydrate
- fasudil hydrochloride
- HA-1077
- fasudil hydrochloride hydrate
- HA1077
- fasudil HCl
- AT-877
- NSC-759827
- ZK-258594
- HA 1077
- Fasudil [INN]
- Fasudilum [INN-Latin]
- 1-(5-Isoquinolinesulfonyl)homopiperazine
- 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-
- UNII-Q0CH43PGXS
- 5-(1,4-diazepane-1-sulfonyl)isoquinoline
- 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
- (5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE
- AT877
- Q0CH43PGXS
- 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE
- CHEMBL38380
- Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine
- Fasudil (INN)
- Fasudilhydrochloride
- AT 877
- Fasudilum
- NSC 759827
- 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]isoquinoline
- CHEBI:43871
- 5-((HEXAHYDRO-1H-1,4-DIAZEPIN-1-YL)SULFONYL)ISOQUINOLINE
- RefChem:597170
- DTXCID9028201
- C04AX32
- HA-1077 (hydrochloride)
- MFCD00866182
- 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline
- Hexahydro-1-(5-isoquinolylsulfonyl)-1H-1,4-diazepine
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