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CILOSTAZOL
SynDRA canonical compound SYN0001919 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PDE3A |
|---|
| Mechanism of action | Phosphodiesterase inhibitor |
|---|
| Indication | claudication |
|---|
| Disease area | cardiology |
|---|
All known targets
- PDE3A
- PDE3B
- CYP2C19
- CYP2C9
- CYP3A5
Mechanisms of action (all sources)
- Phosphodiesterase inhibitor
- PDE3A INHIBITOR
- Phosphodiesterase 3A inhibitor
- PDE3B INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- ESR1
- OPRK1
- NPY2R
- DRD1
- NPY1R
- HRH1
- HRH2
- NPSR1
- GSK3B
- NFE2L2
- MPHOSPH8
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- HDAC6
- KCNH2
- HTR6
- HMGCR
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- LCK
- ABCB11
- GMNN
- SIGMAR1
- TSHR
- TRIM24
- THPO
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- ADCY9
- CP2C9
- CP3A4
- CP3A7
- CSTA
- ESRRA
- GLI3
- NF2L2
- NR5A2
- NSD2
Drug classes
- Phosphodiesterase 3 Inhibitors
- Anti-Asthmatic Agents
- Bronchodilator Agents
- Cardiovascular Agents
- Central Nervous System Agents
- Enzyme Inhibitors
- Fibrinolytic Agents
- Hematologic Agents
- Neuroprotective Agents
- Peripheral Nervous System Agents
- Phosphodiesterase Inhibitors
- Platelet Aggregation Inhibitors
ATC classes
- B01A · ANTITHROMBOTIC AGENTS
Cross-references
Synonyms
- PLETAL
- OPC-13013
- cilostazole
- pletal
- NSC-758936
- OPC-21
- Pletal
- Cilostazole
- Pletaal
- Cilostazolum
- OPC 13013
- Cilostazolum [INN-Latin]
- OPC 21
- UNII-N7Z035406B
- CHEBI:31401
- C20H27N5O2
- BRN 3632107
- MLS000028470
- Otsuka brand of cilostazol
- C 0737
- CL23867
- Cilostazol [INN:JAN]
- Pleta (TN)
- Pletal (TN)
- Pletal, Cilostazol
- Cilostazol (JP15/USAN/INN)
- N7Z035406B
- NSC 758936
- cilostazol (usp monograph)
- cilostazol (usp-rs)
- DTXCID7025132
- RefChem:58562
- MFCD00866780
- NCGC00015207-07
- SMR000058428
- CAS-73963-72-1
- SR-01000003107
Reported adverse events
- Headache
- Tachycardia
- Pain
- Abdominal pain
- Atrial fibrillation
- Cough
- Nausea
- Dizziness
- Dyspepsia
- Infection
- Pharyngitis
- Rhinitis
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