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TOLBUTAMIDE
SynDRA canonical compound SYN0001829 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | ABCC8 |
|---|
| Mechanism of action | ATP channel blocker |
|---|
| Indication | diabetes mellitus |
|---|
| Disease area | endocrinology |
|---|
All known targets
- ABCC8
- KCNJ11
- KCNJ8
- ABCC9
- CYP2B6
- CYP2C19
- CYP2C8
- KCNJ1
- Kcnj11
- Slc22a6
Mechanisms of action (all sources)
- ATP channel blocker
- KCNJ11 BLOCKER
- Sulfonylurea receptor 1, Kir6.2 blocker
- ABCC8 BLOCKER
- KCNJ8 MODULATOR
- KCNJ11 MODULATOR
- ABCC9 BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD2
- ALB
- CYP2C9
- NPY1R
- MLNR
- MC4R
- MC3R
- MBNL1
- MAOA
- LMNA
- ADORA1
- NR3C1
- KCNH2
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- NPY2R
- NTSR1
- HDAC6
- OPRD1
- TDP1
- TBXA2R
- SLCO2B1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SAMHD1
- RXRA
- PTGS2
- PGR
- PDE4D
- PDE3A
- OPRM1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Sulfonylurea
- Hypoglycemic Agents
ATC classes
- V04C · OTHER DIAGNOSTIC AGENTS
- A10B · BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Cross-references
Synonyms
- ORINASE
- ORINASE DIAGNOSTIC
- aglicid
- arkozal
- tolbutamid
- tolumid
- tolumide
- tolbutamide sodium, sterile
- tolbutamide sodium
- tolbutamida
- Tolbutamida
- 1-butyl-3-(p-tolylsulfonyl)urea
- Arkozal
- Butamide
- Diabetamid
- Ipoglicone
- Tolbutamidum
- Willbutamide
- NSC-23813
- NSC-87833
- Glyconon
- Orinase
- Pramidex
- Rastinon
- Aglicid
- Arcosal
- Artosin
- Artozin
- Beglucin
- Butamid
- Butamidum
- Diaben
- Diabesan
- Diabetol
- Diabuton
- Diasulfon
- Diaval
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