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BITHIONOL
SynDRA canonical compound SYN0001826 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Primary target(s) | ESR1 | ESR2 | MCL1 |
|---|
| Mechanism of action | autotaxin inhibitor |
|---|
All known targets
- ESR2
- ESR1
- MCL1
- NAPEPLD
- ADORA2A
- MAPK1
- OPRM1
- SLC22A1
- SLC22A2
- SLC22A3
- SLC47A1
- SLC47A2
Mechanisms of action (all sources)
- NAPEPLD INHIBITOR
- autotaxin inhibitor
- ESR1 INHIBITOR
- CAPN2 INHIBITOR
- ESR2 INHIBITOR
- MCL1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PGR
- ADRB2
- DRD1
- CHRM1
- KCNH2
- NR1I2
- ADRA1A
- NR3C1
- OPRD1
- MMP1
- NR1H4
- OPRK1
- NPY2R
- NPY1R
- NFKB1
- NFE2L2
- MMP9
- MC4R
- MC5R
- PDE4A
- MC3R
- MAPT
- MAPK3
- MAOA
- LMNA
- KDR
- KDM4E
- KCNMA1
- KAT2A
- HTT
- HTR6
- PDE3A
- ACHE
- PDE5A
- RXRA
- VDR
- USP1
- TST
- TSHR
- TP53
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- RAPGEF4
- NLRP1
- PABP1
- PAFA
- PE2R2
- PHGDH
- PPCEL
- PPM1D
- PPME1
- PPP1CA
- PRGR
- RAPGEF3
- RARA
- ACES
- RPGF3
- RPGF4
- S12A5
- S1PR1
- SAE1
- SC6A3
- SMAD2
- SMAD3
- TRFR
- TRHR
- UBA2
- NF2L2
- MRGPRX1
- MDM4
- MDM2
- ANDR
- CP19A
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- DPOLB
- ESRRA
Drug classes
- Anthelmintics
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antiparasitic Agents
- Antiplatyhelmintic Agents
ATC classes
- D10A · ANTI-ACNE PREPARATIONS FOR TOPICAL USE
- P02B · ANTITREMATODALS
Cross-references
Synonyms
- actamer
- bidiphen
- bisoxyphen
- bitionol
- lorothidol
- lorothiodol
- Bitionol
- Bithin
- NSC-47129
- Lorothidol
- Actamer
- 2,2'-Thiobis(4,6-dichlorophenol)
- Bithionol sulfide
- Bisoxyphen
- Bidiphen
- Lorothiodol
- Bitin
- Nobacter
- Bithionolate
- Neopellis
- Vancide BL
- Usaf B-22
- Bithional
- Bithionolum
- 2-Hydroxy-3,5-dichlorophenyl sulfide
- TKhsd
- Bis(2-hydroxy-3,5-dichlorophenyl) sulfide
- Bis(3,5-dichloro-2-hydroxyphenyl) sulfide
- 2,2'-sulfanediylbis(4,6-dichlorophenol)
- Caswell No. 852
- Bitionol [INN-Spanish]
- XL 7
- Bithionolum [INN-Latin]
- 2,2'-Dihydroxy-3,3',5,5'-tetrachlorodiphenyl sulfide
- 2-Hydroxy-3,5-dichlorophenyl sulphide
- 2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfanylphenol
- CP 3438
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