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TADALAFIL
SynDRA canonical compound SYN0001798 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PDE5A |
|---|
| Mechanism of action | Phosphodiesterase inhibitor |
|---|
| Indication | erectile dysfunction |
|---|
| Disease area | urology |
|---|
All known targets
- PDE5A
- PDE11A
- Ache
- KCNH2
- NR2E1
- PDE6A
- PDE6B
- PDE6C
- PDE6D
- PDE6G
- PDE6H
- Pde5a
Mechanisms of action (all sources)
- Phosphodiesterase inhibitor
- PDE5A INHIBITOR
- Phosphodiesterase 5A inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- PDE4A
- PDE4B
- PDE4D
- ABL1
- MC4R
- OPRD1
- NR3C1
- NPY1R
- MLNR
- MC3R
- OPRM1
- MAPK1
- MAOA
- KCND3
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- OPRK1
- PDE1A
- PDE10A
- PTGS2
- TRIM24
- TBXA2R
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- PGR
- ADORA1
- PDE9A
- PDE8A
- PDE7A
- PDE3B
- PDE3A
- PDE2A
- HRH3
- HRH2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- CP3A4
- CP3A7
- KCMB1
- PDE11
- PDE4C
Drug classes
- Phosphodiesterase 5 Inhibitors
- Cardiovascular Agents
- Enzyme Inhibitors
- Phosphodiesterase Inhibitors
- Urological Agents
- Vasodilator Agents
- Phosphodiesterase 5 Inhibitor
ATC classes
- G04B · UROLOGICALS
- OTHER ANTIHYPERTENSIVES
- DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Cross-references
Synonyms
- ADCIRCA
- ALYQ
- Adcirca
- Alyq
- CHEWTADZY
- CIALIS
- Cialis
- ENTADFI
- FINASTERIDE AND TADALAFIL
- OPSYNVI
- Opsynvi
- zalutia
- tardenafil
- tildenafil
- cialis
- IC351
- Tadalafilo
- Chewtadzy
- Tadalafil mylan
- Trans-tadalafil
- IC-351
- LY-450190
- LY450190
- NSC-750236
- NSC-759172
- Adcirca (previously tadalafil lilly)
- Tadalafil component of entadfi
- Tadalafil component of opsynvi
- Tadalafil lilly
- Talmanco (previously tadalafil generics)
- Acdirca
- Tadanafil
- Lilly brand of tadalafil
- Tadalafil [USAN]
- GF-196960
- ICOS 351
- Ic351
Reported adverse events
- Dyspepsia
- Priapism
- Headache
- Myalgia
- Flushing
- Back pain
- Hypertension
- Abdominal pain
- Nasopharyngitis
- Pain in extremity
- Dizziness
- Nasal congestion
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