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DEXMEDETOMIDINE
SynDRA canonical compound SYN0001797 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRA2A | ADRA2B | ADRA2C |
|---|
| Mechanism of action | adrenergic receptor agonist |
|---|
| Indication | sedative |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- ADRA2B
- ADRA2C
- ADRA2A
- ADRA1A
- ADRA1B
- ADRA1D
- Adra1a
- Adra1b
- Adra1d
- Adra2a
- Adra2b
- Adra2c
Mechanisms of action (all sources)
- ADRA2A AGONIST
- Adrenergic receptor alpha-2 agonist
- ADRA2C AGONIST
- ADRA2B AGONIST
- TADA2A AGONIST
- adrenergic receptor agonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR1D
- HTR2B
- SLC6A2
- HTR7
- NTHL1
- HTR1E
- HTR2A
- HTR2C
- HTR3A
- HTR5A
- HTR6
- MUTYH
- NEIL1
- NEIL2
- ADGRF1
- ADRB1
- OPRD1
- PKM
- S1PR1
- SIGMAR1
- SLC6A3
- SLC6A4
- SMUG1
- TDG
- TMEM97
- TP53
- TSHR
- OGG1
- HTR1B
- HTR1A
- DRD1
- ADRB2
- AGTR1
- APLNR
- C5AR1
- CHRM5
- CX3CR1
- CYP1A2
- CYP2C19
- CYP2C9
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Adrenergic alpha2-Agonists
- Central alpha-2 Adrenergic Agonist
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-2 Receptor Agonists
- Adrenergic alpha-Agonists
- Analgesics
- Analgesics, Non-Narcotic
- Central Nervous System Agents
- Central Nervous System Depressants
- Hypnotics and Sedatives
- Neurotransmitter Agents
ATC classes
- N05C · HYPNOTICS AND SEDATIVES
Cross-references
Synonyms
- DEXMEDETOMIDINE HYDROCHLORIDE
- Dexased
- Dexdomitor
- Dexmedesed
- Dexmedvet
- IGALMI
- Igalmi
- PRECEDEX
- Precedex
- Sedexodine
- Sileo
- (S)-Medetomidine
- dexmedetomidine hydrochloride
- dexdor
- dexmedetomidine HCl
- MPV1440
- precedex
- Dexmedetomidina
- Medetomidine, (s)-
- MPV-1440
- Dexmedetomidinum
- Precedex (TN)
- Dexmedetomidine (USAN/INN)
- CHEBI:4466
- RefChem:919964
- Hydrochloride, Dexmedetomidine
- DTXCID00820907
- N05CM18
- MFCD00880557
- UNII-67VB76HONO
- Dexmedetomidinum [INN-Latin]
- Dexmedetomidina [INN-Spanish]
- Dexmedetomidine [USAN:INN:BAN]
- (+)-Medetomidine
- Dexdor (TN)
- Tocris-2023
- NCGC00025347-01
- Dexmedetomidine (Standard)
Reported adverse events
- Bradycardia
- Hypotension
- Nausea
- Abdominal pain
- Acidosis
- Alanine aminotransferase increased
- Arrhythmia
- Blood pressure fluctuation
- Chills
- Hepatic function abnormal
- Hyperhidrosis
- Hypertension
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