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TOLAZOLINE
SynDRA canonical compound SYN0001768 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | ADRA2C |
|---|
| Mechanism of action | Adrenergic receptor antagonist |
|---|
| Indication | reverse sedative |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- ADRA2B
- ADRA2C
- ADRA2A
- ADRA1A
- HRH2
- HRH1
- ADRA1D
- ADRA1B
- Adra2c
- TAAR1
- DRD2
- Adra1d
Mechanisms of action (all sources)
- Adrenergic receptor antagonist
- HRH1 AGONIST
- Histamine H1 receptor agonist
- HRH2 AGONIST
- Histamine H2 receptor agonist
- ADRA1A ANTAGONIST
- Adrenergic receptor alpha antagonist
- ADRA2A ANTAGONIST
- ADRA2C ANTAGONIST
- ADRA1D ANTAGONIST
- ADRA1B ANTAGONIST
- ADRA2B ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA1
- ADORA2A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- LMNA
- MAOA
- MC3R
- MLNR
- NR1I2
- NR3C1
- OPRD1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PPARG
- PTGS2
- SAMHD1
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- HTR1D
- HTR1B
- HTR1A
- CNR1
- ADORA3
- ADRB1
- ADRB2
- AGTR1
- APEX1
- AVPR1A
- CCKAR
- CHRM1
- CHRM2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2D6
- CP3A7
- KCNJ1
- NCF1
- NSD2
Drug classes
- Adrenergic Agents
- Adrenergic alpha-Antagonists
- Adrenergic Antagonists
- Antihypertensive Agents
- Cardiovascular Agents
- Neurotransmitter Agents
- Vasodilator Agents
ATC classes
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
- C04A · PERIPHERAL VASODILATORS
Cross-references
Synonyms
- PRISCOLINE
- tolazoline monohydrochloride
- benzalolin
- benzazoline
- benzidazol
- benzolin
- benzylimidazoline
- imidaline
- imidalin
- phenylmethylimidazoline
- priscoline
- vasodil
- tolazoline hydrochloride
- tolazoline HCl
- Tolazolina
- Tolazine
- NSC-35110
- Artonil
- Benzalolin
- Benzazoline
- Benzidazol
- Benzolin
- Benzylimidazoline
- Divascol
- Imidalin
- Imidaline
- Kasimid;Lambril
- Olitensol
- Peripherine
- Phenylmethylimidazoline
- Prefaxil
- Pridazole
- Priscol
- Priscoline
- Tolazolin
- Tolazolinum
- Vasimid
- Vasodil
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