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GUANETHIDINE
SynDRA canonical compound SYN0001760 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | SLC6A2 |
|---|
| Mechanism of action | adrenergic inhibitor |
|---|
| Indication | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- SLC6A2
- ADRA1A
- ADRA1B
- ADRA1D
- ADRA2A
- ADRA2B
- ADRA2C
Mechanisms of action (all sources)
- SLC6A2 SUBSTRATE
- Norepinephrine transporter substrate
- adrenergic inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NOS2
- ACHE
- NR3C1
- NPY1R
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KDR
- KCNH2
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- NPY2R
- OPRD1
- HRH1
- OPRK1
- USP1
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SIGMAR1
- SAMHD1
- PTPRC
- PTGS2
- PTGS1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Adrenergic Agents
- Antihypertensive Agents
- Cardiovascular Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Sympatholytics
ATC classes
- S01E · ANTIGLAUCOMA PREPARATIONS AND MIOTICS
- C02C · ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
- ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION
Cross-references
Synonyms
- ESIMIL
- GUANETHIDINE MONOSULFATE
- ISMELIN
- abapresin
- ismelin
- octatensine
- oktatensin
- guanethidine monosulfate
- guanethidine sulfate
- Guanetidina
- Esimil
- Abapresin
- Dopam
- Dopom
- Eutensol
- Guanethidinum
- Ismelin
- Isobarin
- Octadin
- Octadine
- Octatensin
- Octatensine
- Oktadin
- Oktatensin
- Oktatenzin
- Sanotensin
- Guanethidine Sulphae
- Guanethidine sulfate
- Ismelin sulfate
- Apo-Guanethidine
- Guanethidine (INN)
- Guanethidine [INN:BAN]
- Guanethidinum [INN-Latin]
- Guanetidina [INN-Spanish]
- Apo-Guanethidine (TN)
- Beta-1-Azacyclooctylethylguanidine
- Su 5864 sulfate (1:1)
- N-(2-Perhydroazocin-1-ylethyl)guanidine
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