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OXYMETAZOLINE
SynDRA canonical compound SYN0001737 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRA2C |
|---|
| Mechanism of action | Adrenergic receptor agonist |
|---|
| Indication | nasal congestion |
|---|
| Disease area | otolaryngology |
|---|
All known targets
- ADRA1A
- ADRA1D
- ADRA2B
- ADRA2C
- ADRA1B
- ADRA2A
- HTR1B
- HTR2C
- HTR1D
- NISCH
- Htr1b
- Htr1a
Mechanisms of action (all sources)
- Adrenergic receptor agonist
- ADRA1A AGONIST
- Adrenergic receptor alpha agonist
- ADRA2A AGONIST
- ADRA2C AGONIST
- ADRA1D AGONIST
- ADRA1B AGONIST
- ADRA2B AGONIST
- TADA2A AGONIST
- HTR1B FULL AGONIST
- HTR1D PARTIAL AGONIST
- HTR2C FULL AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KCNH2
- PTGS2
- DRD2
- DRD3
- ACHE
- MPG
- OPRD1
- OGG1
- NTHL1
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- NPSR1
- NEIL2
- NEIL1
- MMP9
- OPRM1
- MMP1
- MC5R
- MC4R
- MC3R
- MBD4
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KAT2A
- HTR3A
- OPRK1
- PDE3A
- HRH1
- PDE4D
- UNG
- TSHR
- TDP1
- TDG
- TBXAS1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- 5HT1B
- 5HT1D
- 5HT2A
- 5HT2C
- 5HT5A
- CP2D6
- CP3A4
- MDR1
Drug classes
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-Agonists
- Cardiovascular Agents
- Nasal Decongestants
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Respiratory System Agents
- Sympathomimetics
- Vasoconstrictor Agents
- Vasoconstrictor
ATC classes
- D11A · OTHER DERMATOLOGICAL PREPARATIONS
- R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
- S01G · DECONGESTANTS AND ANTIALLERGICS
Cross-references
Synonyms
- Afrin
- KOVANAZE
- Neo-Synephrine 12 Hour
- Nostrilla
- OCUCLEAR
- OXYMETAZOLINE HYDROCHLORIDE
- RHOFADE
- Rhofade
- Sinufrin Plus
- Sudafed OM
- UPNEEQ
- Upneeq
- navasin
- oxylazine
- oxymethazoline
- rhinofrenol
- rhinolitan
- oxymetazoline hydrochloride
- oxymetazoline HCl
- Oximetazolina
- Nasacon
- Operil
- Hazol
- Iliadin
- Nafrine
- Navasin
- Navisin
- Nezeril
- Oximetazolinum
- Oxylazine
- Oxymetazolinum
- Oxymethazoline
- Oxymetozoline
- Rhinofrenol
- Rhinolitan
- Sinerol
- Dristan Long Lasting Mentholated Nasal Spray
- Dristan Long Lasting Nasal Mist
Reported adverse events
- Epistaxis
- Headache
- Application site dermatitis
- Application site erythema
- Application site pain
- Application site pruritus
- Bradycardia
- Dizziness
- Dysgeusia
- Dysphagia
- Hypertension
- Lacrimation increased
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