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NAPHAZOLINE
SynDRA canonical compound SYN0001734 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRA1A | ADRA2A |
|---|
| Mechanism of action | adrenergic receptor agonist |
|---|
| Indication | eye irritation |
|---|
| Disease area | ophthalmology |
|---|
All known targets
- ADRA1A
- ADRA2A
- ADRA2C
- ADRA2B
- ADRA1B
- ADRA1D
- Adra1a
- Adra1b
- Adra1d
- Adra2a
- Adra2b
- Adra2c
Mechanisms of action (all sources)
- ADRA1A AGONIST
- Adrenergic receptor alpha agonist
- ADRA2A AGONIST
- ADRA2C AGONIST
- ADRA1D AGONIST
- ADRA1B AGONIST
- ADRA2B AGONIST
- TADA2A AGONIST
- ADRA1A FULL AGONIST
- ADRA2A PARTIAL AGONIST
- adrenergic receptor agonist
- DRD2 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR1A
- OPRM1
- ACHE
- LMNA
- MAPK1
- MAPT
- MBNL1
- PDE3A
- PDE4A
- PGR
- PTGS1
- SAMHD1
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- TAAR1
- TBXA2R
- MAOA
- KDR
- ADORA3
- KCNH2
- AR
- CHRM1
- CHRM2
- CYP1A2
- CYP2C19
- CYP2C9
- CYP2D6
- CYP3A4
- DRD1
- ESR1
- F2
- GMNN
- HDAC6
- HRH3
- HTR2B
- USP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-Agonists
- Cardiovascular Agents
- Nasal Decongestants
- Neurotransmitter Agents
- Respiratory System Agents
- Vasoconstrictor Agents
ATC classes
- R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
- S01G · DECONGESTANTS AND ANTIALLERGICS
Cross-references
Synonyms
- AK-Con
- ALBALON
- NAFAZAIR
- NAPHAZOLINE HYDROCHLORIDE
- NAPHAZOLINE HYDROCHLORIDE AND PHENIRAMINE MALEATE
- NAPHCON FORTE
- NAPHCON-A
- Naphcon A
- OPCON
- OPCON-A
- Opcon-A
- Privine
- naphazoline nitrate
- naphthazoline
- naphthizine
- nephazoline
- rhinazine
- naphazoline hydrochloride
- naphazoline HCl
- Nafazolina
- Nafazolin
- Antan
- Clearine
- Nafazoline
- Naphazolinum
- Naphthizine
- Opcon
- Nafazolina [DCIT]
- Nafazoline [Spanish]
- Naphazoline Monohydrochloride
- Naphazolinum [Latin]
- Enamine_000333
- Alpha-Naphthylmethyl imidazoline
- Ciba 2020/R
- Nafazolin (TN)
- Naphazoline (INN)
- Naphazoline [INN:BAN]
- Naphazolinum [INN-Latin]
Reported adverse events
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