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UBENIMEX
SynDRA canonical compound SYN0001698 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | RNPEP |
|---|
| Mechanism of action | Leukotriene inhibitor |
|---|
| Indication | acute myeloid leukemia (AML) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- LTA4H
- ANPEP
- RNPEP
- Anpep
- ERAP1
- LAP3
- Lnpep
- MMP2
- NPEPPS
- Rnpep
Mechanisms of action (all sources)
- Leukotriene inhibitor
- leukotriene synthesis inhibitor
- LTA4H INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABL1
- LMNA
- NPY2R
- NPY1R
- NPSR1
- NFE2L2
- MMP9
- MMP14
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- NR3C1
- KCNH2
- IL1RN
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- HDAC3
- NR1I2
- OPRD1
- HDAC1
- SLC15A1
- TRIM24
- TDP1
- TBXAS1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Adjuvants, Immunologic
- Anti-Bacterial Agents
- Anti-HIV Agents
- Anti-Infective Agents
- Anti-Retroviral Agents
- Antibiotics, Antineoplastic
- Antineoplastic Agents
- Antiviral Agents
- Enzyme Inhibitors
- Immunologic Factors
- Protease Inhibitors
Cross-references
Synonyms
- bestatin
- (-)-bestatin
- Bestatin
- NK-421
- NSC-265489
- Bestatin (TN)
- CHEBI:3070
- UPCMLD-DP116
- CHEMBL476869
- SureCN25971
- Ubenimex (JP16/INN)
- Ubenimex (JP17/INN)
- SCHEMBL25971
- GTPL5151
- AC1L972Z
- UPCMLD-DP116:001
- DTXSID4048430
- CHEBI:140702
- ZINC1532730
- ZINC01532730
- BDBM50010142
- AKOS026750073
- NCGC00161660-01
- C00732
- D00087
- ((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-D-leucine
- (2R)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid
- (2R)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid
- (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid
- NK 421
- Ubenimex (Bestatin)
- N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine
- CHEMBL29292
- N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine
- 58970-76-6 (free base)
- (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid
- I0J33N5627
- NSC 265489
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