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RILUZOLE
SynDRA canonical compound SYN0001662 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SCN5A |
|---|
| Mechanism of action | Glutamate inhibitor |
|---|
| Indication | amyotrophic lateral sclerosis (ALS) |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SCN5A
- SCN11A
- SCN10A
- SCN9A
- SCN8A
- SCN7A
- SCN4A
- SCN3A
- KCNN4
- SCN2A
- SCN1A
- TRPC5
Mechanisms of action (all sources)
- Glutamate inhibitor
- SCN1A BLOCKER
- Sodium channel alpha subunit blocker
- SCN5A BLOCKER
- SCN4A BLOCKER
- SCN7A BLOCKER
- SCN2A BLOCKER
- SCN9A BLOCKER
- SCN3A BLOCKER
- SCN11A BLOCKER
- SCN8A BLOCKER
- SCN10A BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- CYP1A2
- DRD1
- ESR1
- ACHE
- NFE2L2
- MC4R
- MC5R
- MLNR
- MMP1
- MMP9
- NFKB1
- NLRP3
- NPC1
- NPY1R
- NPY2R
- NR3C1
- MC3R
- MAPK3
- HMGCR
- HTR2C
- HRH2
- HRH3
- HSD17B10
- HTR1A
- HTR2A
- HTR2B
- HTR3A
- MAPK14
- HTR6
- IDH1
- LCK
- LMNA
- MAOA
- MAPK1
- OPRD1
- OPRK1
- OPRM1
- TACR1
- SLC6A3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- AHR
- ANDR
- CP1A2
- CP2CJ
- CP3A4
- ESRRA
- GCR
- HDAC9
- IFNG
- MDR1
- NSD2
- PRGR
- RARA
Drug classes
- Benzothiazole
- Anticonvulsants
- Central Nervous System Agents
- Excitatory Amino Acid Antagonists
- Neuroprotective Agents
- Neurotransmitter Agents
- Protective Agents
ATC classes
- N07X · OTHER NERVOUS SYSTEM DRUGS
Cross-references
Synonyms
- EXSERVAN
- Exservan
- RILUTEK
- Rilutek
- TIGLUTIK KIT
- Teglutik
- Tiglutik
- rilutek
- rilutor
- 6-Trifluoromethoxybenzothiazol-2-ylamine
- riluzole hydrochloride
- riluzole HCl
- RP54274
- RP-54274
- Riluzol
- BHV-0223
- NSC-753433
- NSC-759823
- Riluzole zentiva
- Tiglutik kit
- Riluzolum
- Riluzole HCl
- ALBB-006046
- BF-37
- PK-26124
- R-116
- Rilutek (TN)
- Riluzol [INN-Spanish]
- Riluzole [USAN:INN]
- Riluzolum [INN-Latin]
- ZERO/001785
- Amino-2 trifluoromethoxy-6 benzothiazole
- Amino-2 trifluoromethoxy-6 benzothiazole [French]
- Riluzole (JAN/USAN/INN)
- PK-26124, RP-54274, Rilutek, Riluzole
- 2-Amino-6-(trifluoromethoxy)-benzothiazole
- 2-Amino-6-(trifluoromethoxy)benzothiazole
Reported adverse events
- Interstitial lung disease
- Nausea
- Pancreatitis
- Asthenia
- Neutropenia
- Tachycardia
- Abdominal pain
- Arthralgia
- Dizziness
- Dry mouth
- Eczema
- Flatulence
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