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LAMOTRIGINE
SynDRA canonical compound SYN0001652 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SCN3A |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | bipolar disorder | epilepsy |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SCN1A
- SCN2A
- SCN3A
- SCN8A
- SCN11A
- SCN4A
- SCN5A
- SCN10A
- SCN9A
- SCN7A
- Scn2a
- dfrA17
Mechanisms of action (all sources)
- Sodium channel blocker
- Serotonin receptor antagonist
- SCN1A BLOCKER
- Sodium channel alpha subunit blocker
- SCN5A BLOCKER
- SCN4A BLOCKER
- SCN7A BLOCKER
- SCN2A BLOCKER
- SCN9A BLOCKER
- SCN3A BLOCKER
- SCN11A BLOCKER
- SCN8A BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PDE3A
- ABCC2
- MC3R
- KCNH2
- LCK
- MAOA
- MAPK1
- MAPK14
- MAPK3
- MC4R
- NPY1R
- MC5R
- MDH1
- MLNR
- MMP1
- MMP9
- KCND3
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- HCAR2
- GMNN
- GIPR
- GHSR
- GCGR
- GALC
- NFE2L2
- NPY2R
- ABCC3
- NR3C1
- UGT1A4
- TBXAS1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Dihydrofolate Reductase Inhibitors
- Anticonvulsants
- Antipsychotic Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Membrane Transport Modulators
- Psychotropic Drugs
- Sodium Channel Blockers
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- LAMICTAL
- LAMICTAL CD
- LAMICTAL ODT
- LAMICTAL XR
- Lamictal
- SUBVENITE
- Subvenite
- lamictal
- lamitrin
- lamotrigin
- BW 430C
- Lamotrigina
- BW-430C
- NSC-759171
- Lamictal cd
- Lamictal odt
- Lamictal xr
- Crisomet
- Labileno
- Lamictin
- Lamiktal
- Lamitor
- Lamotriginum
- Desitin Brand of Lamotrigine
- Faes Brand of Lamotrigine
- Glaxo Wellcome Brand of Lamotrigine
- GlaxoSmithKline Brand of Lamotrigine
- Juste Brand of Lamotrigine
- Lamictal Cd
- Lamictal ODT
- Lamictal XR
- Lamotrigina [Spanish]
- Lamotriginum [Latin]
- GI 267119X
- GW 273293
- L 3791
- EUR-1048
Reported adverse events
- Stevens-Johnson syndrome
- Nausea
- Hypersensitivity
- Lymphadenopathy
- Somnolence
- Arthralgia
- Diplopia
- Rash
- Headache
- Agranulocytosis
- Fatigue
- Vomiting
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